Chemical constituents of the plants of the genus Cleistanthus and their biological activity

Pinho, Paulo; Kijjoa, Anake

doi:10.1007/s11101-006-9027-z

Cited by 24 publications

(23 citation statements)

References 17 publications

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“…5 Cleistanthins A and B are the two main active phytochemicals present in the most of the aerial parts of the plants. 6 Subsequent study with cleistanthin A and B on guinea pig vas deferens confirmed the blockade of phenylephrine induced contractions. 7 Phenylephrine shows selective agonism to alpha 1-adrenoceptor and the fact that cleistanthins A and B block the contractions induced by phenylephrine indicates that cleistanthins A and B have alpha 1-adrenoceptor blocking property.…”

Section: Introductionmentioning

confidence: 85%

Action of Cleistanthins A and B on Alpha Adrenoceptors in Rats

Lakshmanan¹,

Bobby²,

Raveendran³

2016

JYP

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Objectives: Cleistanthins A and B (CAB), active phytochemicals present in Cleistanthus collinus, have been proven to have alpha 1-adrenoceptor blocking property. However action on alpha 2-adrenoceptor is not studied. We aimed to study the action of CAB on alpha 2-adrenoceptor by measuring platelet aggregation, insulin and blood glucose levels with yohimbine as a standard comparator control and alpha 1-adrenoceptor by measuring the blockade of relaxation induced by phenylephrine in the jejunum of Wistar albino rats. Materials and methods: Forty eight adult male Wistar rats were divided into eight drug groups of six each, namely control (CMC 0.5%), yohimbine 2 mg/kg, 10, 30 and 100 mg/kg doses of cleistanthin A and cleistanthin B. Blood samples were drawn at baseline, after 5 h and after high-epinephrine dose (5 mg/kg) from the retro-orbital sinus and used for estimation of platelet aggregation and plasma insulin levels. Blood glucose levels were estimated at six different time points. Degree of jejunal relaxation was studied by relaxing the acetylcholine pre-contracted jejunum with phenylephrine. Results: All groups, except control and cleistanthin A 10 mg/kg group, significantly inhibited the platelet aggregation when compared to the respective baseline values (p<0.05). No significant difference was observed between different drug groups in plasma insulin and blood glucose levels. With regard to phenylephrine induced jejunal relaxation, the median IC 50 for all three doses of cleistanthin A and cleistanthin B 100 mg/kg differ significantly from that of control (CMC 0.5%). Conclusion: CAB block both alpha 1 and 2-adrenoceptorand hence are non-selective alpha-adrenoceptor blockers.

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Section: Introductionmentioning

confidence: 85%

Action of Cleistanthins A and B on Alpha Adrenoceptors in Rats

Lakshmanan¹,

Bobby²,

Raveendran³

2016

JYP

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“…Glycosides such as Cleistanthin A and B are the principle toxins isolated from this poisonous plant, as all parts of this plant is reported as highly toxic (Annapoorani et al, 1984). These cleistanthins have been reported to have anticancer property in vitro and in vivo and may have the probable to become lead compounds to treat cancer (Prabhakaran et There is a significant amount of arylnaphthalide lignans such as diphyllin, collinusin and many other related compounds present in the plant C. collinus (Pinho and Kijjoa, 2007;Satyanarayana et al, 1984). Cleistanthin A and B produce DNA strand breaks in in vitro studies by reducing the viability of the cells.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of shoot tips and nodal segments of Cleistanthus collinus for short term storage and germplasm exchange

Elangomathavan¹,

S²,

Hariharan³

et al. 2017

Int. J. Curr. Res. Biol. Med

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The encapsulation of nodal segments and shoot tips from in vitro raised Cleistanthus collinus (Roxb.) Benth and Hook (Euphorbiaceae) was performed using alginate (Gelling matrix) and calcium chloride (Complexing agent) for short term storage and germplasm preservation. The shoot re-growth frequency of encapsulated nodal segments and shoot tips after storage at 4ºC for different time periods (up to 8 weeks) were also assessed. Different combination and concentration of sodium alginate and calcium chloride was tested for the proper bead formation. The perfect synthetic seeds were obtained through a combination of 4% sodium alginate and 100 mM calcium chloride in half strength Murashige and Skoog medium with 3% sucrose. The maximum shoot re-growth response of encapsulated nodes (95%) and shoot tips (90%) were obtained in MS medium supplemented with 1.0 mg/l BAP after 6 weeks of culture. Encapsulated explants stored at 4ºC also produce maximum shoot regrowth frequency of 5.3 shoots / bead for nodal segments and 3.3 shoots / bead for shoot tips in subsequent weeks of transfer. There was higher response in nodal segments compared to shoot tip explants. The re-grown shoots from the encapsulated explants rooted best on half strength MS medium with 0.5 mg/l IAA. The regenerated plants were successfully hardened and acclimatized.

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“…However, only several species have been chemically studied so far. [1][2][3][4][5][6][7][8][9][10][11] The most popular plant of this genus is C. collinus due to its toxicity. The plants of the Cleistanthus genus are well known for their lignan and terpenoid content.…”

Section: Introductionmentioning

confidence: 99%

“…[1,[4][5][6][7][8][9] Among them, cleistanthin A and cleistanthin B isolated from C. collinus were found to exhibit preferential cytotoxicity in several tumor cell lines. [11][12][13] In our screening program on the flora of Vietnam, the plant C. indochinensis Merr. ex Croiz was collected from Nghe An province.…”

Section: Introductionmentioning

confidence: 99%

Cleistanone: A Triterpenoid from Cleistanthus indochinensis with a New Carbon Skeleton

Thanh¹,

Pham²,

Nguyen³

et al. 2011

Eur J Org Chem

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Cleistanone (1) was isolated from the leaves of Cleistanthus indochinensis and features a new type of triterpenoid carbon skeleton. Its structure was confirmed by X‐ray diffraction analysis. A plausible biosynthetic pathway was proposed for 1 and is thought to proceed through a Wagner–Meerwein rearrangement. Cleistanone (1) was found to show cytotoxic activity against human oral epidermoid carcinoma KB cells.

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Chemical constituents of the plants of the genus Cleistanthus and their biological activity

Cited by 24 publications

References 17 publications

Action of Cleistanthins A and B on Alpha Adrenoceptors in Rats

Action of Cleistanthins A and B on Alpha Adrenoceptors in Rats

Encapsulation of shoot tips and nodal segments of Cleistanthus collinus for short term storage and germplasm exchange

Cleistanone: A Triterpenoid from Cleistanthus indochinensis with a New Carbon Skeleton

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