Chemical Constituents of the Roots of <i>Schisandra chinensis</i>

Peng, Zi Qi; Liu, Yan; Wang, Si Yi; Jiang, Yi; Li, Xiao Mao; Rong, Xiao Hui; Sun, Ye; Pan, Juan; Guan, Wei; Algradi, Adnan Mohammed; Kuang, Hai Xue; Yang, Bing‐You

doi:10.1002/cbdv.202100962

Cited by 4 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The compounds were tested for neuroprotective activity on H 2 O 2 -induced PC12 cell lines. Schineolignin D and quinic acid 4-(E)- o -coumaroylquinic ethyl ester have been shown to have significant neuroprotective effects [ 58 ]. S. chinensis fruit extracts have also been tested for antidepressant effect.…”

Section: Review Methodologymentioning

confidence: 99%

Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology

Jafernik,

Motyka,

Calina

et al. 2024

Chin Med

View full text Add to dashboard Cite

Cancer remains one of the leading causes of mortality worldwide. The search for novel and effective anticancer agents has been a significant area of research. Dibenzocyclooctadiene lignans (DBCLS), derived from the Schisandra genus plants like: S. chinensis, S. sphenanthera, S. henryi, S. rubriflora, S. grandiflora, S. propinqua, and S. glabra, have been traditionally used in various medicinal systems and are known for their myriad health benefits, including anticancer properties. This comprehensive review aimed to collate and critically analyse the recent literature on the anticancer properties of DBCLS, focusing on their mechanistic approaches against different cancer types. An exhaustive literature search was performed using databases like PubMed/MedLine, Scopus, Web of Science, Embase, TRIP database and Google Scholar from 1980 to 2023. Peer-reviewed articles that elucidated the mechanistic approach of these lignans on cancer cell lines, in vivo models and preliminary clinical studies were included. Studies were assessed for their experimental designs, cancer types studied, and the mechanistic insights provided. The studies demonstrate that the anticancer effects of DBCLS compounds are primarily driven by their ability to trigger apoptosis, arrest the cell cycle, induce oxidative stress, modulate autophagy, and disrupt essential signaling pathways, notably MAPK, PI3K/Akt, and NF-κB. Additionally, these lignans have been shown to amplify the impact of traditional chemotherapy treatments, suggesting their potential role as supportive adjuncts in cancer therapy. Notably, several studies also emphasise their capacity to target cancer stem cells and mitigate multi-drug resistance specifically. DBCLS from the Schisandra genus have showcased significant potential as anticancer agents. Their multi-targeted mechanistic approach makes them promising candidates for further research, potentially leading to developing of new therapeutic strategies in cancer management.

show abstract

Section: Review Methodologymentioning

confidence: 99%

Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology

Jafernik,

Motyka,

Calina

et al. 2024

Chin Med

View full text Add to dashboard Cite

show abstract

New triterpenoids and a dibenzocyclooctadiene lignan from the leaves of Schisandra chinensis

Yiqiang

Liu

Wang

et al. 2023

Phytochemistry Letters

View full text Add to dashboard Cite

Three new schinortriterpenoids from the leaves of Schisandra chinensis (Turcz.) Baill

Zhang,

Liu,

Wang

et al. 2023

Natural Product Research

View full text Add to dashboard Cite

Three undescribed schinortriterpenoids, schinensilactones D-F (1-3), together with five known ones, namely, wuweizidilactone A (4), wuweizidilactone C (5), wuweizidilactone F (6), wuweizidilactone J (7) and wuweizidilactone N (8), were isolated from the leaves of Schisandra chinensis (Turcz.) Baill.. The structures of new compounds were established by analysis of their spectroscopic data including MS, IR, 1D-and 2D-NMR spectra. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction and calculated electronic circular dichroism (ECD) spectra. All compounds were evaluated for their neuroprotective effects against H2O2-induced injury in human neuroblastoma SH-SY5Y cell lines. Cell viability was remarkably reduced to 52.33% in H2O2-treated cells. Compounds 5-7 exhibited moderate neuroprotective activities at 50 μM, with cell viability of 64.84%, 67.34% and 63.73%, respectively.

show abstract

Chemical Constituents of the Roots of Schisandra chinensis

Cited by 4 publications

References 17 publications

Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology

Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology

New triterpenoids and a dibenzocyclooctadiene lignan from the leaves of Schisandra chinensis

Three new schinortriterpenoids from the leaves of Schisandra chinensis (Turcz.) Baill

Contact Info

Product

Resources

About