Chemical Constituents of Vernonia cinerea, Part I. Isolation and Spectral Studies of Triterpenes

Misra, T. N.; Singh, R. S.; Upadhyay, Janardan; Srivastava, R. P.

doi:10.1021/np50032a023

Cited by 36 publications

(21 citation statements)

References 10 publications

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“…-Amyrin acetate, 3, and lupenone were also isolated from the stem bark and structures were confirmed by comparing NMR data against literature values (Misra et al, 1984;Carpenter et al, 1980). The H-1 proton resonances showed correlations with the carbon resonances ascribed to the C-19 methyl group carbon (δ 15.7), the C-9 methine carbon (δ 50.8), the C-5 methine carbon (δ 56.2), the C-8 fully substituted carbon (δ 40.6) and the C-3 carbon resonance, previously assigned, in the HMBC spectrum.…”

mentioning

confidence: 63%

Triterpenoids from the African tree Phyllanthus polyanthus

Ndlebe

Crouch

Mulholland

2008

Phytochemistry Letters

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confidence: 63%

Triterpenoids from the African tree Phyllanthus polyanthus

Ndlebe

Crouch

Mulholland

2008

Phytochemistry Letters

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“…Besides these, the plant is used in smoking cessation, cough, fever, malaria, urinary calculi, arthritis and leprosy 12,13,14,15 . The plant possesses antimicrobial 16 , antibacterial 17 , antioxidant 18 , antihelmentic, antiinflammatory, analgesic, antipyretic 17,19,20 , antiflautulent, antispasmodic 8 and antidiuretic properties 21 . Some of the phytochemical compounds that have been reported on the plant include: sterols, flavonoids, sesquiterpene lactones 22 and a terpenoid, 'leupeol acetate' which show antihyperglycaemic and antiulcer properties…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antimicrobial activities of solvent fractions of Vernonia cinerea (L.) Less leaf extract

Sonibare¹,

Aremu²,

Okorie³

2016

Afr H. Sci.

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Background: Vernonia cinerea (L.) Less is used in folk medicine as a remedy for various diseases. Objectives: The present study reports antioxidant and antimicrobial activities of solvent fractions of Vernonia cinerea. Methods: The antioxidant properties of solvent fractions of V. cinerea were evaluated by determining radicals scavenging activity, total flavonoid and phenolic contents measured with the 2,2-diphenyl-1-picryl hydrazyl (DPPH) test, the aluminum chloride and the Folin-ciocalteau methods, respectively. Antimicrobial activities were tested against human pathogenic microorganisms using agar diffusion method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of each active extract were determined. Results: The ethyl acetate fraction having the IC 50 value of 6.50 µg/mL demonstrated comparable DPPH radical-scavenging activity with standard antioxidants, gallic acid and quercetin included in the study. All fractions displayed moderate antimicrobial potential against the tested pathogens with the zone of inhibition that ranged from 9.0 to 13.5 mm. The MIC (1.56 mg/mL) and MBC (3.13 mg/mL) indicated highest susceptibility of Candida albicans in all fractions. Conclusion:The results of this study showed that the solvent fractions of V. cinerea possess antioxidant and antimicrobial activities, hence justifying the folkloric use of the plant for the treatment of various ailments in traditional medicine.

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“…An extract of the plant is used to relieve cold and menstruation-related problems (Verma et al, 1993). The plant has also been used as a tonic, stomachic, and astringent (Misra et al, 1984). The flowers are used to treat conjunctivitis, fever, and rheumatism (Rastogi & Mehrotra, 1991).…”

Section: Introductionmentioning

confidence: 99%