Chemical Diversity of β-Secretase Inhibitors From Natural Resources

Murata, Kazuya

doi:10.1177/1934578x19894819

Cited by 4 publications

(4 citation statements)

References 46 publications

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“…At present, whether the function of γ-secretase in Aβ production can be specifically inhibited without interfering with other important functions of this protease remains unclear [38]. Thus, β-secretase inhibitor candidates are of particular interest to develop, and the majority of AD treatment studies targeting secretase inhibition have focused on this enzyme [39][40][41].…”

Section: Overview Of Enzyme-associated Pathogenesis Mechanisms Of Alz...mentioning

confidence: 99%

“…In total, 87 ChE inhibitors from microorganisms were presented in this review (Figures 2 and 3). Of these, there were fifteen territrem derivatives (13-23, 84-87), fifteen butenolide derivatives (64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78), thirteen terpenoids (10, 30, 49, 50, 53, 56, 57, 59, 79-82), seven alkaloids (1, 5, 7-9, 26, 55), five ether derivatives (29, 36-39), four chromene derivatives (45)(46)(47)(48), three diketopiperazines (31)(32)(33), three polyketides (54,61,83), three hydroxyanthraquinones (40)(41)(42), two dimeric indole derivatives (3,4), two terphenyls (51,52), two lipopeptide epimers (34,35), one phenazine (2), one bicyclic enolphosphates (6), one benzopyran derivatives (11), one flavin (12), one ketal (24), one fatty alcohol (25), one oxaphenalenone dimer (27), one isopentenyl xanthenone (28), one benzophenone (43), one prenyl asteltoxin derivatives…”

Section: Inhibitors On Ache and Buche From Microorganismsmentioning

confidence: 99%

“…Based on the amyloid hypothesis, inhibitors of β-secretase (BACE1)-an amyloid precursor proteolytic enzyme at position 1 beta (BACE)-are also potential candidates for the treatment of AD. Natural sources of BACE1 inhibitors are mainly obtained from plants [40,96], large fungi, marine organisms, and algae [41]. A few studies have investigated secondary compounds from some fungal strains [93,[97][98][99][100].…”

Section: Inhibitors Of Other Targeted Enzymes Of Ad From Microorganismsmentioning

confidence: 99%

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Microorganism-Derived Molecules as Enzyme Inhibitors to Target Alzheimer’s Diseases Pathways

2023

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Alzheimer’s disease (AD) is the most common form of dementia. It increases the risk of other serious diseases and causes a huge impact on individuals, families, and socioeconomics. AD is a complex multifactorial disease, and current pharmacological therapies are largely based on the inhibition of enzymes involved in the pathogenesis of AD. Natural enzyme inhibitors are the potential sources for targeting AD treatment and are mainly collected from plants, marine organisms, or microorganisms. In particular, microbial sources have many advantages compared to other sources. While several reviews on AD have been reported, most of these previous reviews focused on presenting and discussing the general theory of AD or overviewing enzyme inhibitors from various sources, such as chemical synthesis, plants, and marine organisms, while only a few reviews regarding microbial sources of enzyme inhibitors against AD are available. Currently, multi-targeted drug investigation is a new trend for the potential treatment of AD. However, there is no review that has comprehensively discussed the various kinds of enzyme inhibitors from the microbial source. This review extensively addresses the above-mentioned aspect and simultaneously updates and provides a more comprehensive view of the enzyme targets involved in the pathogenesis of AD. The emerging trend of using in silico studies to discover drugs concerning AD inhibitors from microorganisms and perspectives for further experimental studies are also covered here.

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Section: Overview Of Enzyme-associated Pathogenesis Mechanisms Of Alz...mentioning

confidence: 99%

Section: Inhibitors On Ache and Buche From Microorganismsmentioning

confidence: 99%

Section: Inhibitors Of Other Targeted Enzymes Of Ad From Microorganismsmentioning

confidence: 99%

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Microorganism-Derived Molecules as Enzyme Inhibitors to Target Alzheimer’s Diseases Pathways

2023

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“…A previous study showed that corilagin was analyzed in silico, is considered an inhibitor of pancreatic lipase enzymes, and could be used to treat obese patients (Hairulazam et al 2021). Furthermore, Moracin is reported to inhibit the activity of the secretase enzyme; therefore, it can inhibit the synthesis of amyloid in Alzheimer's and dementia conditions (Murata 2019). However, further studies are needed to identify other compounds in broader metabolomics studies.…”

Section: Tannin and Saponin Contents Of Rgl Orangesmentioning

confidence: 99%

Short Communication: Analysis of detected metabolites compounds from the crude extract of Rimau Gerga Lebong oranges fruit (Citrus reticulata ‘RGL’) using LC-QTOF-MS/MS

et al. 2022

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Abstract.Yunita E, Kurniati T, Rosa FL, Melati P, LestariN. 2022. Short Communication: Analysis of detected metabolites compounds from the crude extract of Rimau Gerga Lebong orangesfruit (Citrus reticulata ‘RGL’) using LC-QTOF-MS/MS. Biodiversitas 23: 3778-3783. Rimau Gerga Lebong (RGL) oranges are the leading commodity in Bengkulu Province. However, the content of bioactive compounds in RGL oranges has not been widely reported. This study aims to identify the flavonoid, alkaloids, and tannins from the ethanol extract of RGL oranges. The results of further identification will be used as a reference in further research on molecular docking in various biological activities. Chemical compounds were identified using qualitative tandem liquid chromatography quadrupole time of flight mass spectrometry (LC-QTOF-MS/MS). The measurement of vitamin C levels was carried out using High-Performance Liquid Chromatography (HPLC). The results showed 25 identified compounds, consisting of 6 compounds belonging to the alkaloid group, 17 from the flavonoid group, and 2 from the tannin group. The alkaloid group compounds were 2?, 3?, 6exo-trihydroxy nortopane, 2?, 3?-dihydroxy nortopane, isosalsolin,3?-dihydrocadambine, chelidimerine, and oleracein D. The compounds from identified flavonoid group were chebuloside, neokurarinol, rutinoside, flavonone, glucoside, licochalcone, viscumneoside, and pinnatifinoside. The identified tannins are corilagin and moracin. These compounds that have been identified have biological activity potential as antioxidants, anti-asthma, anti-dementia, and anticancer. The vitamin C content of the ethanol extract of RGL oranges was 0.02±0.0001%. This vitamin C supports the antioxidant activity of RGL orange.

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The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer’s disease

Fronza,

Alves,

Praticò

et al. 2023

Ageing Research Reviews

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Chemical Diversity of β-Secretase Inhibitors From Natural Resources

Cited by 4 publications

References 46 publications

Microorganism-Derived Molecules as Enzyme Inhibitors to Target Alzheimer’s Diseases Pathways

Microorganism-Derived Molecules as Enzyme Inhibitors to Target Alzheimer’s Diseases Pathways

Short Communication: Analysis of detected metabolites compounds from the crude extract of Rimau Gerga Lebong oranges fruit (Citrus reticulata ‘RGL’) using LC-QTOF-MS/MS

The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer’s disease

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