E-Waste consists of all waste from electronic and electrical appliances which have reached their end-of-life or no longer fit for their original intended use also recognized as E-Waste and are destined for recovery, recycling or disposal. Discarded computers, televisions, VCRs, stereos, fax machines, electric lamps, cell phones, audio equipment and batteries if improperly disposed they are severely hazardous to the environment. The electronic industry has emerged as world's fastest growing industry in the world. With increase in usage of electrical and electronic equipment, especially in developing countries the amount of e-waste generated each day is growing enormously has emerged as a global environmental issue. This is because the e-waste comprises multiple components some of which contain toxic substances that can have an adverse impact on human health and the environment if not handled properly. The E-waste has become a matter of concern because of toxic and hazardous present in electronic goods and if not properly managed. These equipments are a complicated assembly of thousand materials, many of which contain highly toxic substances such as brominates, toxic gases, toxic metals, biologically active material, acids, plastics and plastic additives. This paper discusses about the severe adverse impacts of the Ewaste on Human health and environment.