Chemical Instability Op Phospholipids: A Key Factor in Stabilization of Perfluorocarbon Emulsions

Magdassi, Shlomo; Royz, M.; Shoshan, S.

doi:10.1080/01932699108913106

Journal of Dispersion Science and Technology

1991

DOI: 10.1080/01932699108913106

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Chemical Instability Op Phospholipids: A Key Factor in Stabilization of Perfluorocarbon Emulsions

Shlomo Magdassi¹,

M. Royz²,

S. Shoshan

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1992

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Cited by 4 publications

(1 citation statement)

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“…Thus, egg and soy phospholipids are usually used as natural emulsifiers and have been proven to be very useful in the preparation of drugs and cosmetics. The physicochemical properties of phospholipid emulsions have been studied using various oil phases and various sources of phospholipids (6)(7)(8)(9)(10). However, there are unsolved problems regarding the stability of phospholipid emulsions because of their low interfacial adsorptivity compared to other artificial emulsifiers.…”

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Microfiltration and stabilization of egg yolk phospholipid emulsions by a microporous glass membrane

Mine

Nakashima

1997

J Americ Oil Chem Soc

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A microporous glass membrane with a narrowrange pore size was applied for the microfiltration of egg yolk phospholipid emulsions. The oil-in-water and water-in-oil emulsions were successfully filtered using the membrane without any coalescence of oil droplets or the breakdown of the emulsions. The filtrated oil-in-water emulsion was stable for at least 6 wk when stored at 5°C. The results obtained suggest that the technique would be valuable for the precise filtration of emulsions for food uses as well as intravenous fat and/or drug carrier emulsions, and offer the stabilization of the emulsions.

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confidence: 99%

Microfiltration and stabilization of egg yolk phospholipid emulsions by a microporous glass membrane

Mine

Nakashima

1997

J Americ Oil Chem Soc

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Overview of Progress in the Fluorocarbon Approach toin vivoOxygen Delivery

Riess

1992

Biomaterials, Artificial Cells and Immobilization Biotechnology

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The development of fluorocarbon-based oxygen carriers has experienced rapid progress over the past few years. Fluosol has been approved for use during percutaneous transluminal coronary angioplasty (PTCA) for high-risk patients. Its clinical evaluation is being pursued as an adjunct to cancer therapy and for treatment of myocardial infarction in conjunction with thrombolytic therapy. O2-delivery efficacy has been achieved with the development of the new highly concentrated (4 to 5 times more concentrated than Fluosol), fluid, emulsions of perfluorooctyl bromide (perflubron), trade-named Oxygen. The stability of fluorocarbon emulsions has also improved considerably and the new emulsions can be stored unfrozen and are ready for use. The side-effect profile of these emulsions has been characterized as being the normal response of the body's phagocytes to the injection of particles, a response that is considered physiological rather than pathological in nature; it involves some products of arachidonic acid metabolism and can be controlled pharmacologically. Means of further stabilizing fluorocarbon emulsions, involving molecular-diffusion-controlling additives or fluorinated surfactants, including mixed fluorocarbon-hydrocarbon compounds, have been devised. Increased control over in vivo particle recognition, intravascular persistence and side effects, and at adapting emulsion characteristics to specific applications, is being investigated. The range of therapeutic applications is expanding. The concentrated emulsions will be able to serve as a temporary red blood cell substitute in many situations. Acute normovolemic hemodilution with fluorocarbon emulsions, used in conjunction with homologous predonation and other blood-sparing techniques, should afford greater flexibility, increase the margin of safety, and reduce or alleviate the need for autologous blood transfusion during surgical procedures. Fluorocarbon applications in the cardiovascular field include use during PTCA, for cardioplegia and reperfusion, and the treatment of myocardial infarction. Significant tumor growth delay has been achieved when concentrated emulsions are used in conjunction with cancer radio- or chemotherapy. Liquid ventilation has potential as a unique treatment for the adult and infant respiratory distress syndromes and for drug delivery. The radiopaque and versatile perflubron can also be used in contrast agents for diagnosis with computed X-ray tomography, magnetic resonance imaging and ultrasound, allowing the early detection and staging of cancer. Other potential applications investigated include the treatment of cerebral ischemia, organ and limb preservation, use as a tamponade during retinal repair, etc.

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Stability and Stabilization of Fluorocarbon Emulsions Destined for Injection

Riess

Postel

1992

Biomaterials, Artificial Cells and Immobilization Biotechnology

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The factors that have an impact on the stability, and the mechanisms of degradation of fluorocarbon emulsions suited for intravascular use, are briefly reviewed. Various ways of prolonging shelf stability are discussed. The effectiveness of perfluoroalkylated surfactants and/or co-surfactants as stabilizers is demonstrated. New means of stabilizing fluorocarbon-in-water emulsions using molecular dowels are presented.

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Chemical Instability Op Phospholipids: A Key Factor in Stabilization of Perfluorocarbon Emulsions

Cited by 4 publications

References 13 publications

Microfiltration and stabilization of egg yolk phospholipid emulsions by a microporous glass membrane

Microfiltration and stabilization of egg yolk phospholipid emulsions by a microporous glass membrane

Overview of Progress in the Fluorocarbon Approach toin vivoOxygen Delivery

Stability and Stabilization of Fluorocarbon Emulsions Destined for Injection

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