Chemical investigation ofHippophaë rhamnoides. I. The main components of the unsaponifiable part of an extract of the fruit pulp

Salenko, V. L.; Sidelnikov, V. N.; Л, Трошков М; Ралдугин, В. А.; Pentegova, V. A.

doi:10.1007/bf00580456

Cited by 6 publications

(11 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(E)-2-(4′-Hydroxy-3′-hydroxyphenyl)-3,7-dihydroxy-8-geranyl-3″,4″-dioxolophenylpyranochromene-4,7″-dione (10) was obtained as a yellow amorphous powder. HRESIMS: m/z 589.1833 [M − H] − (calcd for C 34 H 29 O 10 , 598.1839).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…3 Many medicinal experiences of H. rhamnoides L. have been clinically used to treat arterial thrombosis, arteriosclerosis, liver fibrosis, chronic hepatitis, oral inflammation, gastric ulcers, skin burns, and radiation damage and in long-term therapy for reduction of cardiovascular risk factors. 4 Previous phytochemical studies on the fruits of H. rhamnoides L. resulted in the isolation and characterization of bioactive ingredients such as vitamins A, C, E, and K, 1 flavonoids, 5 triterpenes, 6 steroids, 3 organic acids, 7 polysaccharides, 8 polyphenols, 9 volatile oils, 10 amino acids, 11 lignans, 12 polysaccharides, 13 and so on. Pharmacological studies had revealed that H. rhamnoides L. displayed a wide variety of bioactivities including antioxidant, 1 anti-inflammatory, 12 antifatigue, 13 antiplatelet, 14 antiulcerogenic, 15 hypolipidemic, 16 hypoglycemic, 16 antivirus, 17 and so on.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Previous phytochemical studies on the fruits of H. rhamnoides L. resulted in the isolation and characterization of bioactive ingredients such as vitamins A, C, E, and K, flavonoids, triterpenes, steroids, organic acids, polysaccharides, polyphenols, volatile oils, amino acids, lignans, polysaccharides, and so on. Pharmacological studies had revealed that H.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Structurally Diverse Flavonolignans with Immunosuppressive and Neuroprotective Activities from the Fruits of Hippophae rhamnoides L.

Wei

Shang

et al. 2020

J. Agric. Food Chem.

View full text Add to dashboard Cite

The fruit of Hippophae rhamnoides L. has been used for centuries in Europe and Asia as a food with high nutritional and medicinal values. In this study, a bioactivity-guided phytochemical investigation of H. rhamnoides L. has resulted in four new dimethylallylated flavonolignans (1–4), four new isopropylpentenone–flavonolignan heterodimers (5–8), two new geranylated flavonolignans (9 and 10), and 14 known flavonolignan derivatives (11–24); they were elucidated by their spectrometric and spectroscopic methods, including HR-ESI-MS, NMR, IR, and UV from the fruit of H. rhamnoides L. for the first time. Among them, compounds 2, 5, 6, 20, and 21 showed potent immunosuppressive activities with IC50 values from 19.42 ± 3.91 to 48.05 ± 12.56 μM. Meanwhile, compounds 1, 4, 11, 12, and 13 showed moderate neuroprotective activities, which increased the cell survival rate from 50.30 ± 4.24% for the model group to 71.63 ± 3.04%, 70.02 ± 4.13%, 61.53 ± 5.93%, 61.08 ± 3.58%, and 65.68 ± 4.88% at 10 μM, respectively. The hypothetical biogenetic pathway and preliminary structure–activity relationship were found and discussed scientifically.

show abstract

Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Structurally Diverse Flavonolignans with Immunosuppressive and Neuroprotective Activities from the Fruits of Hippophae rhamnoides L.

Wei

Shang

et al. 2020

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…The existing technologies of buckthorn processing are based on displacement of the buckthorn oil by vegetable oils (diffusion technology) [5,6], or on the extraction with liquefied gases (CO2, freon-12) under pressure ['7-9] 9 Biologically active compounds also can be isolated from buckthorn by extraction with organic solvents (petroleum ether, pentane, hexane, methylene chloride) [1,4,10].…”

mentioning

confidence: 99%

“…The pharmacological activity of preparations based on the buckthorn oil is due to the biologically active substances, including carotinoids, sterols, etc., present in the fruits [1][2][3][4].…”

mentioning

confidence: 99%