Chemical mutagenesis testing in <i>Drosophila</i>: VIII. Reexamination of equivocai results

Mason, James; Valencia, R.; Zimmering, S.

doi:10.1002/em.2850190307

Cited by 25 publications

(10 citation statements)

References 14 publications

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“…It has been demonstrated that the sex-linked recessive lethal (SLRL) test is more sensitive than other Drosophila tests normally used for germ line genetic damage [Lee et al, 19831. This test has been utilized extensively by the National Toxicology Program for chemical mutagenesis testing [Foureman et al, 1994a,b;Mason et al, 1992;Valencia et al, 1985Valencia et al, , 1989Woodruff et al, 1985;Zimmering et al, 19891. The test has been standardized and results from individual chemical testing from different laboratories 0 1995 Wiley-Liss, Inc. are comparable.…”

Section: Methodsmentioning

confidence: 99%

Mutagenicity testing of nine herbicides and pesticides currently used in agriculture

Kale

Petty

Walker

et al. 1995

Environ and Mol Mutagen

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Nine herbicides and pesticides were tested for their mutagenicity using the Drosophila sex-linked recessive lethal mutation assay. These are Ambush, Treflan, Blazer, Roundup, 2,4-D Amine, Crossbow, Galecron, Pramitol, and Pondmaster. All of these are in wide use at present. Unlike adult feeding and injection assays, the larvae were allowed to grow in medium with the test chemical, thereby providing long and chronic exposure to the sensitive and dividing diploid cells, i.e., mitotically active spermatogonia and sensitive spermatocytes. All chemicals induced significant numbers of mutations in at least one of the cell types tested. Some of these compounds were found to be negative in earlier studies. An explanation for the difference in results is provided. It is probable that different germ cell stages and treatment regimens are suitable for different types of chemicals. larval treatment may still be valuable and can complement adult treatment in environmental mutagen testing.

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Section: Methodsmentioning

confidence: 99%

Mutagenicity testing of nine herbicides and pesticides currently used in agriculture

Kale

Petty

Walker

et al. 1995

Environ and Mol Mutagen

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“…In vivo, maltol-induced micronuclei in mouse bone marrow after intraperitoneal application (Hayashi et al, 1988). Negative results were obtained in a sex-linked recessive lethal mutation assay in Drosophila (Mason et al, 1992). However, the micronucleus assay is considered more relevant than the Drosophila assay.…”

Section: (Q)sar Predictionsmentioning

confidence: 99%

Untitled

2015

EFSA Journal

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“…Injection 0.2 -0.3 μl, 10 000 ppm (10 000 μg/ml) Negative (Mason et al, 1992) Valid, however, test system considered of limited relevance. …”

Section: Drosophila Melanogastermentioning

confidence: 99%

Scientific Opinion on Flavouring Group Evaluation 213, Revision 1 (FGE.213Rev1): Consideration of genotoxic potential for α,β‐Unsaturated Alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19

Flavourings¹

2014

EFS2

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The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of 26 flavouring substances from subgroup 2.7 of FGE.19 in the Flavouring Group Evaluation 213. In the first version of FGE.213 the Panel concluded based on available genotoxicity data that a concern regarding genotoxicity could be ruled out for 07.056, 07.057, 07.075, 07.076, 07.080, 07.117, 07.118, 07.119, 07.120 and 07.168], but for the remaining 15 substances in subgroup 2.7 further genotoxicity data were required. Based on new submitted genotoxicity data, the Panel concluded in FGE.213Rev1 that the concern regarding genotoxicity could be ruled out for 13 substances in subgroup 2.7 07.008, 07.010, 07.041, 07.083, 07.089, 07.108, 07.109, 07.127, 07.136, 07.200, 07.224 For maltol .014], a micronucleus assay after oral application was required in addition to an in vivo Comet assay in order to clarify the genotoxic potential. The outcome would also be applicable to maltyl isobutyrate .525].The remaining 13 substances (including two precursors of a ketone) 07.008, 07.010, 07.041, 07.083, 07.089, 07.108, 07.109, 07.127, 07.136, 07.200, 07.224 and 09.305] could not be evaluated through the Procedure. Accordingly, additional data on genotoxicity were required for representatives of these 13 substances.The flavouring Industry has informed that it does not longer support the representative flavouring substance, piperitenone oxide ], for which the Panel requested additional data. Since the previous version of the FGE, one additional substance has been included in subgroup 2.7, tr-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)but-2-en-1-one , which is structurally related to the other substances for which the genotoxic potential could not be ruled out.In FGE.213Rev1 the Panel has evaluated the new data submitted by the Industry in response to the data request presented in FGE.213. Based on these new data the Panel concluded that the genotoxicity concern could be ruled out for the representative substances beta-ionone .008], betadamascone .083], nootkatone .089], 2,6,6-trimethylcyclohex-2-en-1,4-dione [FLno: 07.109] and the nine substances that they represent, being 07.010, 07.041, 07.108, 07.127, 07.136, 07.200, 07.224 and 09.305].The Panel considered also the new data submitted for maltol .014] and concluded that for maltol .014] and maltyl isobutyrate .525] the concern for genotoxicity could not be ruled out.

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Chemical mutagenesis testing in Drosophila: VIII. Reexamination of equivocai results

Cited by 25 publications

References 14 publications

Mutagenicity testing of nine herbicides and pesticides currently used in agriculture

Mutagenicity testing of nine herbicides and pesticides currently used in agriculture

Untitled

Scientific Opinion on Flavouring Group Evaluation 213, Revision 1 (FGE.213Rev1): Consideration of genotoxic potential for α,β‐Unsaturated Alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19

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