Chemical mutagenesis testing in <i>Drosophila</i>. III. Results of 48 coded compounds tested for the national toxicology program

Valencia, R.; Mason, James; Woodruff, Robert W.; Zimmering, S.

doi:10.1002/em.2860070309

Cited by 102 publications

(43 citation statements)

References 17 publications

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“…The assay with CHO cells did meet FIFRA guidelines; however, it was unclear if the sister chromatid exchange assay met FIFRA guidelines due to insufficient information. One sex-linked recessive lethal (SLRL) assay in Drosophila melanogaster had equivocal results (Valencia et al, 1985), but there was also insufficient information to determine if this study met FIFRA guidelines.…”

Section: Iiia4 Carcinogenicity -Weight Of Evidencementioning

confidence: 93%

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Evaluating Soil Solarization for Weed Control and Strawberry (Fragariaxananassa) Yield in Annual Plasticulture Production

Samtani¹,

Derr²,

Conway³

et al. 2017

Weed Technol

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Field studies were initiated in the 2013-14 and 2014-15 growing seasons to evaluate the potential of soil solarization (SS) treatments for their efficacy on weed control and crop yields and to compare SS to 1,3-dichloropropene (1,3-D)+chloropicrin (Pic) fumigation. Each replicate was a bed with dimension 10.6 m long by 0.8 m wide on top. The center 4.6 m length of each bed, referred to as plots, was used for strawberry plug transplanting and data collection. Treatments included: i) 1,3-D+Pic (39% 1,3-dichloropropene+59.6% chloropicrin) that was shank-fumigated in beds at 157 kg ha−1and covered with VIF on August 30 in both seasons; ii) SS for a 6 wk duration initiated on August 15, 2013 and August 21, 2014 by covering the bed with 1 mil clear polyethylene tarp; iii) SS for a 4wk duration initiated on September 6, 2013 and September 3, 2014; iv) SS 4 wk treatment initiated September 6, 2013 and September 3, 2014 and replaced with black VIF on October 4, 2013 and October 1, 2014 and v) a nontreated control covered with black VIF on October 4, 2013 and October 1, 2014. In both seasons, following completion of the preplant treatments, ‘Chandler’ strawberry was planted in two rows at a 36 cm in-row spacing in plots during the first wk of October. Over both seasons, the 6 wk SS treatment consistently lowered the weed density compared to the nontreated control. Weed density in the 6wk SS treatment was not statistically different from the 4wk SS treatments in the 2013-14 growing season. In both seasons, crop yield in the 4 wk SS was significantly lower than other treatments.

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Section: Iiia4 Carcinogenicity -Weight Of Evidencementioning

confidence: 93%

“…A sex-linked recessive lethal assay was conducted in which Drosophila melanogaster Canton-S wild-type males were fed chloropicrin (91% pure) at 0 and 150 ppm for 4 hours or injected at 0 and 100 ppm (Valencia et al, 1985). Males were then mated with 3 harems of Basc virgin females to produce 3 broods of 3, 2, and 2, days.…”

Section: Iie1 Gene Mutationmentioning

confidence: 99%

Evaluating Soil Solarization for Weed Control and Strawberry (Fragariaxananassa) Yield in Annual Plasticulture Production

Samtani¹,

Derr²,

Conway³

et al. 2017

Weed Technol

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“…Our procedures for the SLRL assay have been described elsewhere [Woodruff et al, 1984Valencia et al, 1985;Yoon et al, 1985;Zimmering et al, 19851. Briefly, each chemical was tested for the ability to induce recessive lethals after being fed to adult males. If no significant mutation induction was observed, the compound was retested after injection.…”

Section: Materials a N D Methodsmentioning

confidence: 99%

Chemical mutagenesis testing in Drosophila: VIII. Reexamination of equivocai results

Mason

Valencia

Zimmering

1992

Environ and Mol Mutagen

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Twelve percent of the chemicals tested for mutagenicity by the National Toxicology Program (NTP) using the Drosophila sex-linked recessive lethal assay have been classified as producing equivocal results. We have reexamined the published data and the criteria used to determine mutagenicity in light of the historical distribution of the concurrent negative controls for this project. Many of the chemicals that originally produced equivocal results have been retested under code. As a result of changes to incorporate a comparison with the historical control in the algorithm used to determine mutagenicity and as a result of new data accumulated, 4 of the 25 chemicals that gave equivocal results are judged to be mutagenic, and 11 others are judged to be nonmutagenic under our test conditions.

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“…HCTZ, administered either by injection or in the feed, did not induce sex-linked recessive lethal mutations in Drosophila melanogaster [Valencia et al, 1985]. HCTZ was also negative for micronucleus and sister chromatid exchange induction in Chinese hamsters, negative in the mouse spermatogonia assay, and negative in the mouse dominant lethal assay [EMEA, 1999].…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity of hydrochlorothiazide in cultured human lymphocytes. I. Evaluation of chromosome delay and chromosome breakage

Andrianopoulos

Stephanou

Demopoulos

2005

Environ and Mol Mutagen

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Hypertension is often treated with diuretics, like hydrochlorothiazide (HCTZ). Previous results on the in vitro genotoxicity of HCTZ are equivocal. In the present study, we have evaluated the genotoxicity of HCTZ in cultured human lymphocytes using the Cytokinesis Blocked Micronucleus (CBMN) assay. In addition, micronucleus (MN) induction was analyzed by Fluorescence In Situ Hybridization (FISH) with an alpha-satellite DNA centromeric probe to distinguish between clastogenic and aneugenic effects. Lymphocyte cultures from 32 healthy adults were exposed to 5 and 40 microg/ml HCTZ. Age, gender, and smoking were evaluated as factors affecting the MN analysis. We found that HCTZ increased MN frequencies. FISH analysis revealed that HCTZ exerts its genotoxicity more strongly at the 40 microg/ml concentration, and principally through chromosome delay (aneugenicity). Multiregression analysis of our results confirmed the known effect of age and gender on MN induction in human lymphocytes. Smoking was also a confounding factor for MN induction, especially for centromere-negative MN frequencies. Under the experimental conditions used, only age had a clear positive effect on the response of lymphocytes to HCTZ. These data indicate that HCTZ produces micronuclei in cultured human lymphocytes by a mechanism that involves chromosome delay and to a lesser extent through chromosome breakage.

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Chemical mutagenesis testing in Drosophila. III. Results of 48 coded compounds tested for the national toxicology program

Cited by 102 publications

References 17 publications

Evaluating Soil Solarization for Weed Control and Strawberry (Fragariaxananassa) Yield in Annual Plasticulture Production

Evaluating Soil Solarization for Weed Control and Strawberry (Fragariaxananassa) Yield in Annual Plasticulture Production

Chemical mutagenesis testing in Drosophila: VIII. Reexamination of equivocai results

Genotoxicity of hydrochlorothiazide in cultured human lymphocytes. I. Evaluation of chromosome delay and chromosome breakage

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