1971
DOI: 10.1016/0020-708x(71)90082-2
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Chemical processing of cyclotron- produced 67Ga

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Cited by 31 publications
(8 citation statements)
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“…The curve of assayed samples shows an initial rapid decline in radioactivity lasting approximately 20 h and a second phase with a half-life of 40.7 h. The false elevation in the gentamicin 123I (2) 131i (1) WITc-pertechnetate (2) "Tc-sulfacolloid (2) 'rc-albumin microspheres (2) [76SeJmethionine (2) 67Ga citrate (10) level fell below 1 ,ug/ml at 7.8 days after 67Ga administration. The decay curve (not shown) of radioactivity in sera spotted directly onto filters is parallel to, but slightly higher than, that obtained from assayed samples.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The curve of assayed samples shows an initial rapid decline in radioactivity lasting approximately 20 h and a second phase with a half-life of 40.7 h. The false elevation in the gentamicin 123I (2) 131i (1) WITc-pertechnetate (2) "Tc-sulfacolloid (2) 'rc-albumin microspheres (2) [76SeJmethionine (2) 67Ga citrate (10) level fell below 1 ,ug/ml at 7.8 days after 67Ga administration. The decay curve (not shown) of radioactivity in sera spotted directly onto filters is parallel to, but slightly higher than, that obtained from assayed samples.…”
Section: Resultsmentioning
confidence: 99%
“…In patients with impaired renal function, the duration of interference may be even greater. The method presented in this report to circumvent the problem of 67Ga interference in the radioenzymatic assay of aminoglycosides is a modification of a procedure originally described by Nachtrieb and Fryxell (2) and subsequently used in the commercial production of 67Ga (1). The effectiveness of the extraction procedure is due to the high solubility of gallium as the chloride in diisopropyl ether in the presence of 7.2 N HCI.…”
Section: Resultsmentioning
confidence: 99%
“…[15] The earlier work established that dialkyl ethers, and in particular Et 2 O and i Pr 2 O, efficiently and selectively extracted gallium from 5-7 M hydrochloric acid solutions in batch. [18,[22][23][24][25][26] In view of the dialkyl ethers being generally nontoxic, readily available, low boiling-point liquids with significant variation in hydrophobicity, we decided to evaluate this class of compounds for further development in LLE and membrane-based separation of Ga from Zn. Since the *Ga production yield and its extractability, as well as the *Ga vs. Zn selectivity, is expected to depend on zinc and HCl concentrations, we decided to explore both high (5.…”
Section: System Designmentioning
confidence: 99%
“…Table 1 shows that each of these nuclides are produced by charged particle bombardment in a cyclotron. For example, 67 Ga is produced by irradiating an enriched 6S Zn (normal abundance for this isotope is 18.6%) target with 12-22 MeV protons [13]. To isolate the 67 Ga, the target is dissolved in HCl, the Ga extracted with isopropyl ether, back extracted from the ether into HCl and the solution is evaporated to dryness.…”
Section: Diagnostic Applicationsmentioning
confidence: 99%