Chemical Profile and Bioactivity Evaluation of Salvia Species from Eastern Europe

Luca, Simon Vlad; Skalicka-Woźniak, Krystyna; Mihai, Cosmin Teodor; Gradinaru, Adina Catinca; Mandici, Alexandru; Ciocârlan, Nina; Aprotosoaie, Ana Clara

doi:10.3390/antiox12081514

Cited by 10 publications

(4 citation statements)

References 57 publications

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“…The antioxidant activity was investigated by the DPPH radical scavenging method. ,, First, HYP E solutions were prepared at 0.2, 0.1, 0.05, and 0.025 wt % in 80% ethanol solution. Then, 50 μL of each solution was added to 2.95 mL of DPPH solution in methanol ( A 517 nm = 1.0 ± 0.5) and shaken vigorously.…”

Section: Methodsmentioning

confidence: 99%

Highly Compressible, Superabsorbent, and Biocompatible Hybrid Cryogel Constructs Comprising Functionalized Chitosan and St. John’s Wort Extract

Platon,

Ghiorghita,

Lazar

et al. 2024

Biomacromolecules

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Biobased porous hydrogels enriched with phytocompounds-rich herbal extracts have aroused great interest in recent years, especially in healthcare. In this study, new macroporous hybrid cryogel constructs comprising thioureacontaining chitosan (CSTU) derivative and a Hypericum perforatum L. extract (HYP E ), commonly known as St John's wort, were prepared by a facile one-pot ice-templating strategy. Benefiting from the strong interactions between the functional groups of the CSTU matrix and those of polyphenols in HYP E , the hybrid cryogels possess excellent liquid absorption capacity, mechanical resilience, antioxidant performance, and a broad spectrum of antibacterial activity simultaneously. Thus, owing to their design, the hybrid constructs exhibit an interconnected porous architecture with the ability to absorb over 33 and 136 times their dry weight, respectively, when contacted with a phosphate buffer solution (pH 7.4) and an acidic aqueous solution (pH 2). These cryogel constructs have extremely high compressive strengths ranging from 839 to 1045 kPa and withstand elevated strains of over 70% without developing fractures. Moreover, the water-swollen hybrid cryogels with the highest HYP E content revealed a complete and instant shape recovery after uniaxial compression. The incorporation of HYP E into CSTU cryogels enabled substantial improvement in scavenging reactive oxygen species and an expanded antibacterial spectrum toward multiple pathogens, including Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and fungi (Candida albicans). Cell viability experiments demonstrated the cytocompatibility of the 3D cryogel constructs, which did not induce changes in the fibroblast morphology. This work showcases a simple and effective strategy to immobilize HYP E extracts on CSTU 3D networks, allowing the development of novel multifunctional platforms with promising potential in hemostasis, wound dressing, and dermal regeneration scaffolds.

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Section: Methodsmentioning

confidence: 99%

Highly Compressible, Superabsorbent, and Biocompatible Hybrid Cryogel Constructs Comprising Functionalized Chitosan and St. John’s Wort Extract

Platon,

Ghiorghita,

Lazar

et al. 2024

Biomacromolecules

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“…In addition, S. officinalis dropped the elevated levels of ALT and AST in the serum. The azathioprine-induced oxidative stress was relieved through MDA reduction and counteracting the inhibitory effect of azathioprine on glutathione, catalase and superoxide dismutase activity [136].…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

“…S. miltiorrhiza and other Salvia species have been shown to inhibit acute liver injury induced by D-galactosamine, protect against CCl4-induced acute and chronic liver injury and fibrosis, and protect against hepatic fibrosis and apoptosis induced by biliary obstruction in rats [136].…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

Natural Compounds of Salvia L. Genus and Molecular Mechanism of Their Biological Activity

Zhumaliyeva,

Zhussupova,

Zhusupova

et al. 2023

Biomedicines

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The study of medicinal plants is important, as they are the natural reserve of potent biologically active compounds. With wide use in traditional medicine and the inclusion of several species (as parts and as a whole plant) in pharmacopeia, species from the genus Salvia L. are known for the broad spectrum of their biological activities. Studies suggest that these plants possess antioxidant, anti-inflammatory, antinociceptive, anticancer, antimicrobial, antidiabetic, antiangiogenic, hepatoprotective, cognitive and memory-enhancing effects. Phenolic acids, terpenoids and flavonoids are important phytochemicals, which are primarily responsible for the medicinal activity of Salvia L. This review collects and summarizes currently available data on the pharmacological properties of sage, outlining its principal physiologically active components, and it explores the molecular mechanism of their biological activity. Particular attention was given to the species commonly found in Kazakhstan, especially to Salvia trautvetteri Regel, which is native to this country.

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“…Several biological activities have been reported for sage extracts, such as antibacterial, anticancer, anticholinesterase, antinociceptive, hypoglycemic, hypolipidemic, liver-protective, antioxidant, etc. (Figure 1) [8][9][10][11][12]. Recently, the anti-radical activity of S. officinalis L. against uranium toxicity, with uranium being a highly radioactive toxic heavy metal, has been suggested [13].…”

Section: Introductionmentioning

confidence: 99%

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

Iacopetta,

Ceramella,

Scumaci

et al. 2023

Antioxidants

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Nutrition has crucial effects and a significant role in disease prevention. Recently, nutraceuticals have attracted much attention in scientific research due to their pleiotropic effects and relatively non-toxic behavior. Among the biological effects displayed by plants belonging to the Lamiaceae family, such as antibacterial, anticancer, anti-inflammatory, and anticholinesterase, sage is well known for its antioxidant properties and is a rich source of numerous compounds that are biologically active, amongst them polyphenols, with more than 160 types identified. In this review we summarized some of the significant studies published in the last decade reporting the most employed extraction methods and the different assays that are useful for establishing the antioxidant properties of some sage species. Even though the scientific literature contains plenty of data regarding the antioxidant properties of many sage species, further studies are needed in order to gain a deeper understanding of the mechanism of action and the compounds responsible for their antioxidant activity. Finally, it should be taken into account that the data on the antioxidant properties of sage extracts are often difficult to compare with each other, since a series of variables in the extraction procedures, the type of assay used, and standardization may affect the final result.

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Chemical Profile and Bioactivity Evaluation of Salvia Species from Eastern Europe

Cited by 10 publications

References 57 publications

Highly Compressible, Superabsorbent, and Biocompatible Hybrid Cryogel Constructs Comprising Functionalized Chitosan and St. John’s Wort Extract

Highly Compressible, Superabsorbent, and Biocompatible Hybrid Cryogel Constructs Comprising Functionalized Chitosan and St. John’s Wort Extract

Natural Compounds of Salvia L. Genus and Molecular Mechanism of Their Biological Activity

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

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