Chemical profile, antioxidant and anti-inflammatory properties of Miconia albicans (Sw.) Triana (Melastomataceae) fruits extract

Corrêa, José Guilherme de Souza; Bianchin, Mirelli; Lopes, Ana Paula; Silva, Evandro; Ames, Franciele Queiroz; Pomini, Armando M.; Carpes, Solange Teresinha; Rinaldi, Jaqueline de Carvalho; Melo, Raquel Cabral; Kioshima, Érika Seki; Bersani-Amado, Ciomar Aparecida; Pilau, Eduardo Jorge; Carvalho, João Ernesto de; Ruiz, Ana Lúcia Tasca Góis; Visentainer, Jesuí V.; Santin, Silvana Maria de Oliveira

doi:10.1016/j.jep.2021.113979

Cited by 15 publications

(15 citation statements)

References 103 publications

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“…The authors reported higher content of phenolic compounds and flavonoids among them, quercetin, kaempferol, and their glycosilated derivates by UHPLC-QTOF-MS/MS. In favor of our results, their extracts presented approximately 95% viability after 24 h of exposure to 1000 µg/mL on in vitro assay carried out on the Vero cell line [33]. However, there are no previous reports that demonstrate the toxicity of compounds 1, 2, and 3 on Vero cell lines.…”

Section: Cytotoxicity Aassaycontrasting

confidence: 71%

Active Flavonoids from Colubrina greggii var. greggii S. Watson against Clinical Isolates of Candida spp.

et al. 2021

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Candida albicans is the most commonly implicated agent in invasive human fungal infections. The disease could be presented as minimal symptomatic candidemia or can be fulminant sepsis. Candidemia is associated with a high rate of mortality and high healthcare and hospitalization costs. The surveillance programs have reported the distribution of other Candida species reflecting the trends and antifungal susceptibilities. Previous studies have demonstrated that C. glabrata more frequently presents fluconazole-resistant strains. Extracts from Mexican plants have been reported with activity against pulmonary mycosis, among them Colubrina greggii. In the present study, extracts from the aerial parts (leaves, flowers, and fruits) of this plant were evaluated against clinical isolates of several species of Candida (C. albicans, C. glabrata, C. parapsilosis, C. krusei, and C. tropicalis) by the broth microdilution assay. Through bioassay-guided fractionation, three antifungal glycosylated flavonoids were isolated and characterized. The isolated compounds showed antifungal activity only against C. glabrata resistant to fluconazole, and were non-toxic toward brine shrimp lethality bioassay and in vitro Vero cell line assay. The ethyl acetate and butanol extracts, as well as the fractions containing the mixture of flavonoids, were more active against Candida spp.

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Section: Cytotoxicity Aassaycontrasting

confidence: 71%

Active Flavonoids from Colubrina greggii var. greggii S. Watson against Clinical Isolates of Candida spp.

et al. 2021

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“…Sinapate helps to improve pathogen resistance for Botrytis cinerea by UV-B radiation in Arabidopsis (Demkura and Ballaré, 2012). Vitexin has been reported to have inhibitory effects on Gram-negative bacteria, especially Pseudomonas aeruginosa and Bordetella petrii (Das et al, 2016;Rath et al, 2016;Corrêa et al, 2021), and vitexin's glucoside has a significant antioxidant effect (Fang et al, 2016;Wu et al, 2021). Thus, the enriched metabolites in the "R1" sample may contribute to the disease resistance to tea gray blight disease.…”

Section: Discussionmentioning

confidence: 99%

Metabolome and Microbiome Signatures in the Leaves of Wild Tea Plant Resources Resistant to Pestalotiopsis theae

Zhang

Chang-yu

et al. 2022

Front. Microbiol.

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Tea (Camellia sinensis) is an important crop that is mainly used in the food industry. This study using the metabolome and microbiome investigates the resistance factors of wild tea plant resources against tea gray blight disease, which is caused by Pestalotiopsis theae (Sawada) Steyaert. According to the interaction analysis of tea leaves and pathogenic fungus, the resistance of wild tea plant resource “R1” (Resistance 1) to tea gray blight disease was significantly higher than that of wild tea plant resource “S1” (Susceptibility 1). The difference between “R1” and “S1” in the metabolome was obvious. There were 145 metabolites that significantly changed. The phenolic acids and flavonoids were the major increased categories in “R1,” and it included 4-O-glucosyl-sinapate and petunidin-3-o-(6”-o-p-coumaroyl) rutinoside. Six metabolic pathways were significantly enriched, including aminoacyl-tRNA biosynthesis, flavone, and flavonol biosynthesis. In terms of bacteria, there was no significant difference between “S1” and “R1” in the principal component analysis (PCA). Pseudomonas was the major bacterial genus in “S1” and “R1.” In addition, each of the two resources had its own predominant genus: Cellvibirio was a predominant bacterial genus in “S1” and Candidatus_competibacter was a predominant bacterial genus in “R1.” In terms of fungi, the fungal diversity and the abundance of the two tea plant resource samples could be distinguished clearly. The fungal component of “S1” was more abundant than that of “R1” at the genus level. Toxicocladosporium was the predominant fungal genus of “S1,” and Filobasidium was the predominant fungal genus of “R1.” The relative abundance of unclassified-norank-norank-Chloroplast and Penicillium were significantly different between “S1” and “R1.” Penicillium was identified as a potential biomarker. They correlated with some metabolites enriched in “S1” or “R1,” such as L-arginine and quercetin-3-o-(2”-o-rhamnosyl) rutinoside-7-o-glucoside. Overall, phenolic acids, flavonoids, and Penicillium could be functional metabolites or microorganisms that contributed to improving the resistance of wild tea plant resources to tea gray blight disease.

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“…Despite the scarcity of information in the literature regarding chemical and pharmacological approaches to S. angulosa and C. Lucens, comparison with previous studies on M. albicans shows that the extraction of phenolics using the binary mixture of ethyl acetate and methanol was higher than the values published by Pieroni et al, (2011) and Corrêa et al, (2021) for the methanolic extract from the leaves (70.04 mg g -1 )…”

Section: Mixture Planning and Total Phenolicsmentioning

confidence: 72%

“…Another studied plant, M. albicans, is a tree of the Melastomaceae family found in tropical regions. In Brazil it is known as canela-de-velho, and its leaves and aerial parts are widely consumed in teas prepared by infusion and in ointments for the treatment of rheumatism, arthrosis, and arthritis (CORRÊA et al, 2021;QUINTANS-JÚNIOR et al, 2020). Some authors attribute the antioxidant, anti-inflammatory, and analgesic properties to the presence of pentacyclic triterpenes, phenolic acids, and flavonoids (CORRÊA et al, 2021;CUNHA et al, 2017;LIMA et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Avaliação do potencial antioxidante e fotoprotetor em plantas coletadas na Mata Atlântica do sul da Bahia

Silva

Lima

Bandeira

et al. 2022

CeN

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As ações terapêuticas e farmacológicas de plantas decorrente da ação de metabólitos secundários e uma importante para a valorização e conhecimento da biodiversidade rica do Brasil. Nesse contexto, este estudo objetivou a investigação por métodos in vitro da ação antioxidante e fotoprotetora de extratos otimizados por planejamentos de mistura de solventes de Copaifera lucens Dwyer, Schnella angulosa (Vogel) Wunderlin e Miconia albicans (SW) Triana coletadas na Mata Atlântica o Sul da Bahia, Brasil. Os resultados limitados a dependência da concentração de DPPH na atividade antioxidante e o da S. angulosa (CE 50 21,37 e IAA 1,40) e (CE 5037,21 e IAA 0,80) foram considerados ativos. Entretanto, a atividade fotoprotetora não foram relevantes (FPS <6).

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Chemical profile, antioxidant and anti-inflammatory properties of Miconia albicans (Sw.) Triana (Melastomataceae) fruits extract

Cited by 15 publications

References 103 publications

Active Flavonoids from Colubrina greggii var. greggii S. Watson against Clinical Isolates of Candida spp.

Active Flavonoids from Colubrina greggii var. greggii S. Watson against Clinical Isolates of Candida spp.

Metabolome and Microbiome Signatures in the Leaves of Wild Tea Plant Resources Resistant to Pestalotiopsis theae

Avaliação do potencial antioxidante e fotoprotetor em plantas coletadas na Mata Atlântica do sul da Bahia

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