Chemical profile, nutraceutical and anti-phytobacterial properties of the essential oil from Dalea foliolosa (Fabaceae)

Villa‐Ruano, Nemesio; Hernández, Yesenia Pacheco; Rosas, E. Rubio; Reyes, José A. Zárate; Lozoya‐Gloria, Edmundo; Durán, Ramiro Cruz

doi:10.9755/ejfa.2017.v29.i9.99

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…In this case, linalool (10-17%) and cryptone (22-30%) were the main constituents, together with a very relevant sesquiterpene fraction accounting for 10-23% of the whole amount. In this respect, caryophyllene oxide (5-15%) and α-cadinol (1-6%) were the most abundant sesquiterpenoids [22].…”

Section: Discussionmentioning

confidence: 99%

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The Flower Essential Oil of Dalea mutisii Kunth (Fabaceae) from Ecuador: Chemical, Enantioselective, and Olfactometric Analyses

Gilardoni

Montalván

Ortiz

et al. 2020

Plants

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An essential oil was distilled with 0.25% yield from fresh flowers of Dalea mutisii Kunth, a native species mainly growing in the Andean region of Ecuador. A total of 50 compounds were identified, and most of them were quantified. The chemical composition was characterized by the prevalence of monoterpene hydrocarbons (>90%). Major components were α-pinene (42.9%), β-pinene (15.1%), β-phellandrene (12.6%), myrcene (6.7%), and (Z)-β-ocimene (5.4%). The essential oil was then submitted to enantioselective analysis, with a 2,3-diethyl-6-tert-butyldimethylsilyl-β-cyclodextrin-based capillary column. An enantiomeric excess was measured for (1R,5R)-(+)-α-pinene (91.6%), (1R,5R)-(+)-β-pinene (15.2%), (R)-(−)-α-phellandrene (4.8%), and (R)-(−)-β-phellandrene (88.8%), whereas (R)-(+)-limonene was enantiomerically pure. A gas chromatography–olfactometry (GC–O) analysis was additionally carried out on this pleasantly fragrant essential oil, following an aroma extract dilution analysis (AEDA) approach. Main odorants were α-pinene, β-pinene, α-phellandrene, and (Z)-β-ocimene, with dilution factors (FD) of 8, 4, 2, and 2, respectively.

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Section: Discussionmentioning

confidence: 99%

“…[21], D. foliosa (A. Gray) Barneby [22], and D. strobilacea Barneby [23], with the latter being the corresponding species. With regard to D. mutisii, only two studies were found on its nonvolatile metabolites, describing prenylated flavonoids as the main compounds [24,25].…”

Section: Introductionmentioning

confidence: 99%

The Flower Essential Oil of Dalea mutisii Kunth (Fabaceae) from Ecuador: Chemical, Enantioselective, and Olfactometric Analyses

Gilardoni

Montalván

Ortiz

et al. 2020

Plants

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“…p-Nitrophenylα-D-glucopyranoside and 4-nitrophenyl-4,6-ethylidene-a-D-maltoheptaoside were used as substrates for AG and AA, respectively. The hydrolytic activity of both enzymes was recorded at 405 nm as previously described (Villa-Ruano et al, 2017). The inhibitory examination on PL was determined by the hydrolysis of fatty acids from triolein at 340 nm (Villa-Ruano et al, 2013).…”

Section: Assays On Target Enzymesmentioning

confidence: 99%

Comparative effect of resveratrol, carnosic acid and hernandulcin on target enzymes and biochemical markers linked to carbohydrate and lipid metabolism in mice

Villa-Ruano,

Ramírez-García,

Landeta-Cortés

et al. 2023

Emir J Food Agric

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Resveratrol (RV), carnosic acid (CA) and hernandulcin (HE; a non-caloric sweetener) are envisioned as promising nutraceuticals to designnew functional foods for improving lipid and carbohydrate metabolism. This study aimed to investigate the in vitro inhibitory effectof these molecules on specific enzyme targets and their capacity to improve distinctive markers associated to carbohydrate and lipidmetabolism in murine model. The enzymes explored were alpha-amylase, alpha-glucosidase, and pancreatic lipase whereas ICR malemice were used for in vivo testing. Saturation curves (10-200 µM mL-1) and Lineweaver-Burk regressions suggested that RV, CA andHE exerts non-competitive inhibition on pancreatic lipase, alpha-glucosidase and alpha-amylase but, CA produced a strong competitiveactivity on alpha-amylase. RV was more effective to inhibit alpha-glucosidase (IC50, 22.1 µM) whereas CA was the most effective toinhibit both alpha-amylase (IC50, 11.7 µM) and pancreatic lipase (IC50, 31.5 µM). The effects of the oral administration of RV (300 mg/kg) HE (100 mg/kg) and CA (100 mg/kg) as well as the simultaneous administration of the three compounds at the same concentration was also explored in normoglycemic and diabetic mice. In addition, the prolonged administration of these substances combined with hypercaloric/atherogenic diet for 30 days was performed. Our results revealed a clear modulatory activity in both postprandial glucose and triglyceride levels as well an improvement in biochemical markers of mice treated with hypercaloric/atherogenic diet. The administration of HE produced a notable change (p < 0.01) in postprandial glucose assimilation at 60 min post-treatment in diabetic mice, whereas the other two compounds exerted a stronger depletion of glucose levels from 30 to 120 min post-treatment. A similar trend was recorded by RV and CA in postprandial triglyceride content, however, the latter compound was more effective (p < 0.05) at lower doses than RV. The simultaneous administration of the three compounds produced a significant improvement (p < 0.01) in biochemical parameters associated to carbohydrate (insulin and glucose) and lipid metabolism (total cholesterol, LDL-c, HDL-c, triglycerides, leptin, and adiponectin).Outstandingly, the mixture of the three compounds was more effective (p < 0.01) than the administration of sole compounds to amelioratethe side effects of the hypercaloric/atherogenic diet. Finally, the body weight of treated mice significantly decreased (from 5 to 20%; p < 0.05) in comparison with mice only fed with hypercaloric/atherogenic diet. Our results suggest that mixtures of RV, HE and CA may work better than their sole administration in mice and part of their biological activity could be associated with their inhibitory properties on the enzyme targets evaluated in this investigation. Keywords: Carnosic acid; Hernandulcin; Resveratrol; Hypoglycemic; Hypolipidemic; Murine model; Target enzymes

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Nutraceutical Activity of Anthocyanins from the Edible Berries of Rhamnus pompana

Pacheco‐Hernández,

Lozoya‐Gloria,

Rangel‐Galván

et al. 2023

Chemistry & Biodiversity

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We present the inhibitory properties of the R. pompana anthocyanin fraction (RPAF) and its major constituents on alpha‐glucosidase (AG), pancreatic lipase (PL), HMG‐CoA reductase, and ornithine decarboxylase (ODC). The effect of RPAF was also evaluated in ICR male mice subjected to oral glucose tolerance test (OGTT) and hypercaloric/atherogenic diet for 30 days. RP‐HPLC‐MS profiling revealed that RPAF contained five major anthocyanins and induced slight inhibition on PL and HMG‐CoA reductase (IC50, 245‐338 µg mL‐1) whereas strong activity on AG and ODC (IC50, 130‐133 µg mL‐1) was observed. Kinetic studies and molecular docking with pelargonidin‐3‐O‐rutinoside (P3R) on ODC, revealed changes in Km (0.9514‐0.9746 mM) and Vmax (1.96‐2.32 µmol mg‐1min‐1) suggesting mixed inhibition and molecular interaction with two active sites of ODC. P3R showed antiproliferative activity (IC50, 46.5 µM) and decreased polyamine accumulation in DLD‐1 cells. The results of OGTT confirmed that RPAF regulates postprandial glucose levels in diabetic animals which experienced a significant glucose depletion (30 %; p < 0.001) from 30 to 120 min post‐treatment. Prolonged supplementation of RPAF caused significant decrease (p < 0.001) in plasma glucose, total cholesterol, LDL‐c and triglycerides as well as significant increase (p < 0.001) of HDL‐c compared with normoglycemic untreated animals.

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Chemical profile, nutraceutical and anti-phytobacterial properties of the essential oil from Dalea foliolosa (Fabaceae)

Cited by 6 publications

References 8 publications

The Flower Essential Oil of Dalea mutisii Kunth (Fabaceae) from Ecuador: Chemical, Enantioselective, and Olfactometric Analyses

The Flower Essential Oil of Dalea mutisii Kunth (Fabaceae) from Ecuador: Chemical, Enantioselective, and Olfactometric Analyses

Comparative effect of resveratrol, carnosic acid and hernandulcin on target enzymes and biochemical markers linked to carbohydrate and lipid metabolism in mice

Nutraceutical Activity of Anthocyanins from the Edible Berries of Rhamnus pompana

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