Chemical Profiling and Antioxidant Activity of Tanacetum vulgare L. Wild-Growing in Latvia

Abstract

The Tanacetum vulgare L. (Tansy) has several ethnobotanical uses, mostly related to the essential oil and sesquiterpene lactones, whereas information regarding other compounds is scarce. This research is designed to characterize the phenolic compounds (flavonoids, phenolic acids, and tannins) to analyze the thujone (which is toxic in high concentrations) content and to detect the antioxidant activity (DPPH assay) of extracts. The main highlights of our work provide a chemical profile of phenolic compounds of T. vulgare harvested from different regions of Latvia, as well as simultaneously support the ethnomedicinal uses for wild T. vulgare through the integration of phenolic compounds as one of the value constituents of leaves and flowers. The extraction yield was 18 to 20% for leaves and 8 to 16% for flowers. The total phenol content in the extracts of T. vulgare as well as their antioxidant activity was different between collection regions and the aerial parts ranging from 134 to 218 mg GAE/g and 32 to 182 mg L−1, respectively. A remarkable variation in the thujone (α + β) content (0.4% up to 6%) was detected in the extracts. T. vulgare leaf extracts were rich in tannins (up to 19%). According to the parameters detected, the extracts of T. vulgare could be considered promising for the development of new herbal products.

Anthelmintic Activity of Tanacetum vulgare L. (Leaf and Flower) Extracts against Trichostrongylidae Nematodes in Sheep In Vitro

“…Asteraceae family plants contain more terpenes (sesquiterpene lactones and santonin [ 13 ]) and phenolics (phenolic acids and lignans [ 30 ]). Tansy from Latvia contains different phenolic compounds; in a study from Latvia, chemical compounds in extracts of tansy were tested, where total flavonoids, phenolic acids, total phenols, tannins, specific phenols (quinic acid, gallic acids, catechin, chlorogenic acid, caffeic acid, rutin, quercetin, kaempferol, and apigenin) and essential oils (thujone) was detected [ 31 ]. Overall, phenolic compounds are the secondary metabolites, which are often related to antiparasitic effect.…”

“…Overall, phenolic compounds are the secondary metabolites, which are often related to antiparasitic effect. The leaf extracts (135–219 mg GAE/g) contain more phenolic compounds than flower extracts (127–155 mg GAE/g) [ 31 ]. This could be the reason why in this study leaf extracts showed stronger anthelmintic activity than flower extracts.…”

Phytochemistry and Allelopathic Effects of Tanacetum vulgare L. (Tansy) Extracts on Lepidium sativum L. (Garden Pepper Cress) and Lactuca sativa L. (Lettuce)

“…Also, luteolin, O-caffeoyl glucoside (C15H18O9), pontica epoxide (C13H10O), 6-methoxykaempferol and 5,7,3'-trihydroxy-3,6,4',5'-tetramethoxyflavone were identified in tansy root extracts in 50% methanol. The majority of the compounds identified in tansy extracts in 50% methanol (Table 3) had previously been characterized [1,[4][5][6][7][8][9][10]. It should be noted that some common flavonoids (apigenin, rutin, (iso)quercitrin, eupatorin, hispidulin, etc.…”

“…In the ethno-pharmacology of many European countries (including Lithuania), the plant has been used for many purposes: as an anthelmintic remedy, for the healing of neurological, digestive, skin, support-motion, and respiratory system diseases [1][2][3][4][5][6]. Recent investigations have shown that T. vulgare is a vast natural resource with a wide range of pharmacological properties, including antioxidant [2][3][4][5][7][8][9][10][11], antibiotic [3,10], anti-inflammatory [3,11], cytotoxic [1][2][3]7,11], antimicrobial [1,2,[10][11][12], anthelmintic [13], diuretic [14], vascular [15], antibacterial [8,10,16], enzyme inhibition [7,16] and neuroprotective activity [7,17].…”

“…Numerous recent investigations focused on tansy volatile compounds and essential oils [1,3,6,8,12,13,22,27,[35][36][37][38][39][40]. The phytochemical analyses of the plant extracts revealed that it contains flavonoids, tannins, phenolic compounds, carotenoids, and their derivatives [2,4,6,7,[9][10][11][12]16,24].…”