Chemical profiling and assessment of neurobiological properties of Veronica teucrium and Veronica jacquinii methanolic extracts

Veronica persica (Persian speedwell) is a flowering plant local to Eurasia. In this study, several analyses were done to discover the antimicrobial and scolicidal activities and acetyl cholinesterase (AChE), tyrosinase (TYR), lipoxygenase (LOX), and xanthine oxidase (XO) inhibitory activities of V. persica extract.The results presented that B. subtilis was the most susceptible to the extract (MIC = 40.3 μg/mL), while P. aeruginosa was the most resistant strain (MIC = 250.9 μg/mL) among all bacteria evaluated. The extracts demonstrated significant activity versus E. granulosus (P < 0.5) with dose-dependent inhibitions of the protoscolices. The analyzed plant extract exhibited a high AChE and TYR inhibitory activity 55.3% and 52.7% (at the highest utilized dose -3 mg/mL), respectively. The extract also showed high anti-inflammatory activities in analyses tested. Our research proposed that extract of this plant could be promising to the human health, markedly in the infectious, neurodegenerative and inflammatory disorders.

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“…In addition, Živković el al. (2017) showed that V. teucrium and V. jacquinii methanol extracts inhibit AChE and TYR enzymes (60).…”

Section: Discussionmentioning

confidence: 99%

Veronica persica Poir. extract – antibacterial, antifungal and scolicidal activities, and inhibitory potential on acetylcholinesterase, tyrosinase, lipoxygenase and xanthine oxidase

Sharifi‐Rad

Tayeboon

Niknam

et al. 2018

Cell Mol Biol (Noisy-le-grand)

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“…Ferulic acid (peak 8, t R 42.30 min) was easy to identify by its MS ions at m/z 191 [M-H] − and at m/z 149 [ferulic acid-H-CO 2 ] − [37]. Moreover, peaks 2 (t R 7.86 min), 3 (t R 11.21 min), and 6 (t R 23.77 min) were tentatively assigned as gallic, protocatechuic, and syringic acids, respectively, based on the UV spectra, MS 2 fragmentation pattern and previous report [38]. Gallic and syringic acids were only detected in the aqueous fraction.…”

Section: Resultsmentioning

confidence: 69%

“…The UV spectra of peaks 5 and 8 showed the same absorption maximum at 332nm typical of cinnamic acid derivatives [34]. Peak 5 (t R 21.22 min) was identified as caffeic acid by comparing with a reference compound and according to its deprotonated molecular ion [M-H] − at m/z 179 and MS 2 ions at m/z 161 [caffeic acid-H-H 2 O] − and at m/z 135 [caffeic acid-H-CO 2 ] − [37, 38]. Ferulic acid (peak 8, t R 42.30 min) was easy to identify by its MS ions at m/z 191 [M-H] − and at m/z 149 [ferulic acid-H-CO 2 ] − [37].…”

Section: Resultsmentioning

confidence: 99%

LC-ESI-MS/MS Phenolic Profile of Volutaria lippii (L.) Cass. Extracts and Evaluation of Their In Vitro Antioxidant, Antiacetylcholinesterase, Antidiabetic, and Antibacterial Activities

Salah

Smaoui

Abdennabi³

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Volutaria lippii (L.) Cass., an indigenous perennial herb from the Tunisian flora, belongs to the medicinally important genus Volutaria Cass. (Asteraceae) which comprises eighteen species widely distributed in the Irano-Turanian and Mediterranean Basin. In this study, five different extracts from Tunisian Volutaria lippii (L.) Cass. were evaluated for their in vitro antioxidant, antiacetylcholinesterase, antidiabetic, and antibacterial activities as well as for their total phenolic and flavonoid contents. The results indicated that the ethyl acetate and aqueous fractions have the highest levels in phenolic and flavonoid contents and showed remarkable antioxidant activities using DPPH (IC50= 11.50±0.57 and 28.81±1.35μg/mL, respectively), total antioxidant capacity (105.21±0.01 and 98.77±0.02 mg vitamin E/g extract, respectively), and reducing power (EC50= 55.40±2.00 and 66.65±1.40 μg/mL, respectively) methods. Furthermore, they exhibited noticeable antiacetylcholinesterase and antidiabetic activities and a moderate antibacterial effect when compared to that of standards. Principal component analysis allowed highlighting the ethyl acetate extract for its interesting acetylcholinesterase enzyme (AChE) and alpha-amylase activities and the aqueous fraction for its remarkably antibacterial activity, and their richness in phytochemical content. Interestingly, the LC-ESI-MS/MS analyses of both fractions allowed the identification of ten phenolic acids and eight flavonoids. The 3-O-caffeoylquinic and 3,4-di-O-caffeoylquinic acids constituted the most abundant components in the two fractions. Taken together, these findings demonstrated, for the first time, that Volutaria lippii (L.) Cass. is a potential source of biological active compounds which could be used in a wide range of fields, namely, nutrition and complementary pharmacological drug.

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Chemical profiling and assessment of neurobiological properties of Veronica teucrium and Veronica jacquinii methanolic extracts

Cited by 2 publications

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Veronica persica Poir. extract – antibacterial, antifungal and scolicidal activities, and inhibitory potential on acetylcholinesterase, tyrosinase, lipoxygenase and xanthine oxidase

Veronica persica Poir. extract – antibacterial, antifungal and scolicidal activities, and inhibitory potential on acetylcholinesterase, tyrosinase, lipoxygenase and xanthine oxidase

LC-ESI-MS/MS Phenolic Profile of Volutaria lippii (L.) Cass. Extracts and Evaluation of Their In Vitro Antioxidant, Antiacetylcholinesterase, Antidiabetic, and Antibacterial Activities

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