Chemical Profiling and In Vitro Antiurolithiatic Activity of Pleurolobus gangeticus (L.) J. St.- Hil. ex H. Ohashi &amp; K. Ohashi Along with Its Antioxidant and Antibacterial Properties

Mohan, Prasobh K.; Krishna, T. P. Adarsh; Thirumurugan, A.; Kumar, T. Senthil; Kumari, B. D. Ranjitha

doi:10.1007/s12010-022-04017-0

Cited by 8 publications

(4 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In comparison, at 10 mg/ml, the smallest percentage of inhibition was seen at 46.14 percent-the half maximum inhibitory concentration (IC 50 was found to be 54.7179). The ability of ACV to scavenge DPPH reactive oxygen species are produced when different crystal types, such as calcium phosphate, uric acid and CaOx, are exposed to renal epithelial cells where further reactive oxygen species contributes to the formation of kidney stones [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

GC–MS Based Metabolite profiling, Antioxidant and Antiurolithiatic Properties of Apple Cider Vinegar

Singh

Chitra

et al. 2023

Future Sci. OA

View full text Add to dashboard Cite

Aim: To perform in vitro analysis of antioxidant and antiurolithiasis to carry out GC–MS-based metabolite profile. Materials & methods: The effect of apple cider vinegar (ACV) in vitro, antioxidant and GC–MS analysis was evaluated. The antioxidant studies were performed. In vitro techniques included nucleation, aggregation and growth assay. Results & conclusion: The presence of polyphenols, flavonoids, alkaloids and carbohydrates was shown. Concentrations from 5–30 μg/ml could dissolve calcium oxalate (p < 0.05) in vitro. The IC50 value of ACV in DPPH was found to be around 7 μg/ml and the IC50 value of the ACV in ABTS assay was around 9 μg/ml. Different phytocompounds were obtained from GC–MS analysis. ACV can be consumed to prevent kidney stones which seems helpful to the current therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

GC–MS Based Metabolite profiling, Antioxidant and Antiurolithiatic Properties of Apple Cider Vinegar

Singh

Chitra

et al. 2023

Future Sci. OA

View full text Add to dashboard Cite

show abstract

“…A wide variety of uropathogens may cause infection stones, including E. coli, S. aureus, P. mirabilis, K. pneumoniae, Streptococcus sp. and P. aeruginosa ( Mohan et al, 2022 ; Raj et al, 2023 ). Therefore, biofabricated To-AgNPs are promising anti-uropathogenic agents and may act as stone preventers.…”

Section: Discussionmentioning

confidence: 99%

Structural characterization, antioxidant and anti-uropathogenic potential of biogenic silver nanoparticles using brown seaweed Turbinaria ornata

Raj,

Muthukumar,

Dahms

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

Alternative treatment strategies for urinary tract infections (UTIs) are becoming more necessary due to increasing drug resistance patterns in uropathogens. Nanoparticle-based therapeutics is emerging as a way to treat UTIs. In the present study, using Turbinaria ornata extract, silver nanoparticles (AgNPs) were synthesized, characterized, and their anti-uropathogenic activity was evaluated. The stability and formation of synthesized To-AgNPs were confirmed by UV-visible spectroscopy, FTIR, XRD, SEM, and DLS. An FTIR spectrum confirmed the presence of seaweed functional groups in To-AgNPs, a XRD analysis confirmed their crystalline nature, and SEM imaging confirmed their spherical nature with an average size of 73.98 nm with diameters ranging from 64.67 to 81.28 nm. This was confirmed by TEM results. DLS determined that the cumulant hydrodynamic diameter of To-AgNPs was 128.3 nm with a PdI of 0.313 and the zeta potential value were found to be –63.3 mV which indicates the To-AgNPs are negatively charged and more stable. DPPH assays were used to assess the antioxidant activity of biosynthesized To-AgNPs, while an agar well diffusion method was used to test the antibacterial activity against uropathogens, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, and Klebsiella pneumoniae. The To-AgNPs showed the highest susceptibility to S. aureus (15.75 ± 0.35 mm) and E. coli (15 ± 0.7 mm) with MIC values of 0.0625 and 0.125 mg/ml, respectively in macro broth dilution method and observed considerable membrane damage under CLSM and SEM. To-AgNPs displayed stronger antioxidant and antimicrobial activity, suggesting they may be developed as a new class of antimicrobial agents for treating UTIs.

show abstract

“…Various medicinal plants contain an unsaturated phytosterol known as stigmasterol or stigmasterin ( Mohan et al, 2022 ). Stigmasterol has been considered as bactericidal property in grape leaf extract.…”

Section: Bioactive Properties Of Grape Leavesmentioning

confidence: 99%

“…The antiobesity effect of many phenolic acids has been reported. Vanillic acid reduces obesity by the activation of the AMPKpathway (AMP-activated protein kinase) ( Mohan et al, 2022 ), AMPK (AMP-activated protein kinase) acts as energy homeostasis, as an enzyme it is involved in the energy metabolism of in liver, muscle and fat tissue, inhibition of AMPK is one of the most important cause of accumulation of liver fat. The enzyme ACC, i.e., Acetyl-CoA carboxylase was phosphorylated by the activation of AMPK.…”

Section: Bioactive Properties Of Grape Leavesmentioning

confidence: 99%

Valorization of grape (Vitis vinifera) leaves for bioactive compounds: novel green extraction technologies and food-pharma applications

Singh,

Rasane,

Kaur

et al. 2023

Front. Chem.

View full text Add to dashboard Cite

Grape leaves, scientifically known as Vitis vinifera, the primary by-product obtained after the processing of grapes, are gathered in enormous amounts and disposed of as agricultural waste. For more sustainable agriculture and better food systems, it is crucial to investigate these byproducts’ nutritional values. The primary bioactive compounds present in grape leaves are quercetin, resveratrol, caffeic acid, kaempferol, and gallic acid, which favour pharmacological effects on human health such as antioxidant, anti-inflammatory, anti-obesity, anti-diabetic, and hepatoprotective. Furthermore, grape leaves extract has been used as a functional ingredient for creating both food and non-food products. The aim of the current review is to review the nutritional and phytochemical composition of various varieties of grape leaves, their health-promoting characteristics and their applications. The study also highlights the various extraction techniques including conventional and non-conventional methods for extracting the various bioactive compounds present in grape leaves. Grape leaves bioactives can be extracted using environmentally safe and sustainable processes, which are in line with the rising demand for eco-friendly and healthful products worldwide. These methods are perfectly suited to the changing needs of both customers and industries since they lessen environmental effect, enhance product quality, and offer financial advantages.

show abstract

Chemical Profiling and In Vitro Antiurolithiatic Activity of Pleurolobus gangeticus (L.) J. St.- Hil. ex H. Ohashi & K. Ohashi Along with Its Antioxidant and Antibacterial Properties

Cited by 8 publications

References 79 publications

GC–MS Based Metabolite profiling, Antioxidant and Antiurolithiatic Properties of Apple Cider Vinegar

GC–MS Based Metabolite profiling, Antioxidant and Antiurolithiatic Properties of Apple Cider Vinegar

Structural characterization, antioxidant and anti-uropathogenic potential of biogenic silver nanoparticles using brown seaweed Turbinaria ornata

Valorization of grape (Vitis vinifera) leaves for bioactive compounds: novel green extraction technologies and food-pharma applications

Contact Info

Product

Resources

About