Chemical quality evaluation of Antrodia cinnamomea fruiting bodies using phytomics similarity index analysis

Abstract

The fruiting body of Antrodia cinnamomea is used as a medicinal mushroom in Taiwan and is found on the inner cavity of the endemic species Cinnamomum kanehirai. In this study, phytomics similarity index (PSI) analysis was employed for the chemical quality evaluation of the A. cinnamomea fruiting bodies from different strains, and grown on various substrates. The results indicated that the different types of A. cinnamomea fruiting bodies contain eight index compounds, and that it was difficult to discriminate between them solely on the basis of those index compounds. In our research, we used PSI scores to assess the metabolite similarity of the fruiting bodies of A. cinnamomea. It was revealed that fruiting bodies from various A. cinnamomea strains grown on different culture substrates produce distinct PSI scores. We concluded that PSI analysis had good selectivity on the different types of A. cinnamomea fruiting bodies.

Metabolomic Profiling of Different Antrodia cinnamomea Phenotypes

“…Previous studies have pointed out that white and red AC have similar index components, including antcin A, antcin B, antcin C, antcin H, antcin K, dehydrosulfurenic acid, dehydroeburicoic acid, and 1,4-dimethoxy-2,3-methylenedioxy-5-methylbenzene (non-triterpenoid) [ 19 ]. In addition, consistent with previous studies, the content of total triterpenoids in the fruiting bodies of RAC was higher than WAC [ 19 , 20 ], while there is no literature report on the total triterpenoid content of YAC.…”

Anti-Oxidant, Anti-Mutagenic Activity and Safety Evaluation of Antrocin

“…4 Mean body weight gain on the 28th day (g) = (28th − 21st)BW (g). 5 NC: negative control (olive oil). 6 Data are expressed as the mean ± SD (n = 5).…”

“…Since the 1990s, more and more scientists have invested in the research of AC and its ingredients. More than one hundred different compounds have been isolated from AC, and the percentage of each compound may vary depending on different culture methods [ 5 , 6 ]. Most of the compounds belong to polysaccharides, benzenoids, diterpenes, triterpenoids, steroids, and maleic and succinic acid derivatives.…”

Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo

“…As a mainstream form of complementary and alternative medicine, traditional Chinese medicine (TCM) has been widely accepted for cancer patients because of its beneficial effects and lack of serious side effects 3 . Antrodia cinnamomea is a rare fungus that grows in Taiwan, China, distributing over broad-leaved forests at an altitude of 200–2000 m. Pharmacological studies have shown that A. cinnamomea has anti-tumor, liver protection, immune regulation, inhibiting vascular neointimal formation, lowering blood pressure and cholesterol, inhibiting platelet aggregation, and other physiological activities 4 , 5 , 6 , 7 , 8 , 9 . Of the numerous functions, the effects of hepatoprotective especially anti-HCC were the most often reported.…”