Mobile sensor network is applied in information collection in emergencies. As the mobile sensor network in real environment is widely deployed with different height and the redundancy of the sensor node needs to be as low as possible, therefore, it is necessary to effectively deploy mobile sensor nodes in the 3D space to have reasonable layout and optimized density. To this end, we established the optimization model of mobile sensor network deployment and solved the model with chemical reaction optimization (CRO). The experimental results have shown that compared with traditional particle swarm optimization (PSO), CRO algorithm can achieve reasonable deployment more rapidly and enhance the network performance evaluation value effectively. The reasonable deployment of mobile sensor network node is very significant to information collecting, postperiod decision-making, and rapid rescuing work in emergencies.