High school chemistry and biology courses often face challenges in integrating interdisciplinary and complex topics like human digestion, leading to unsatisfactory learning outcomes and diminished student interest. This study introduces a new teaching experiment that simulates the digestive process through hands-on chemical methods, allowing students to visualize biochemical changes and gain a deeper understanding of essential concepts. Structured around the CORE learning cycle (Chemical Observations, Representations, and Experimentation), the experiment guides students through enzyme functions, nutrient breakdown, and the testing of digestive products. This approach is designed to enhance comprehension, encourage inquiry, prompt students to formulate new hypotheses, design experiments, and foster scientific reasoning. By engaging students in active learning, the experiment stimulates curiosity and motivates exploration beyond the standard curriculum.