Chemical Screening, Antioxidant Potential and Antiangiogenic Effect of Microporus Xanthopus (fr.) Kuntze, Ganoderma Orbiforme (fr.) Ryvarden and Polyporus Fasciculatus (pat) lloyd, Medicinal Mushrooms from Gabon

Juliette-Ornely, Orango-Bourdette; Calixte, Eyi-Ndong Hugues; Roger, Ndong-Atome Guy; Rick-Léonid, Ngoua Meye Misso; Sima-Obiang, Cédric; Ondo, Joseph-Privat; Louis-Clement, Obame-Engonga

doi:10.46624/ajphr.2018.v6.i10.002

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…It contains a variety of chemical components, including alkaloids, flavonoids, steroids, triterpenoids, and coumar, which have the potential to have positive pharmacological effects with applications in agriculture, medicine, and other fields [ 31 ]. According to reports, it has anthelmintic [ 32 ], antibacterial [ 33 ], anticancer [ 1 ], and antiangiogenic properties.…”

Section: Introductionmentioning

confidence: 99%

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Gebreyohannes,

Sbhatu

2023

International Journal of Analytical Chemistry

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Secondary metabolites are hidden gems in mushrooms. Understanding these secondary metabolites’ biological and pharmacological effects can be aided by identifying them. The purpose of this work was to profile the mycochemical components of the extracts of Auricularia auricula judae, Microporus xanthopus, Termitomyces umkowaani, Trametes elegans, and Trametes versicolor to comprehend their biological and pharmacological capabilities. Mushroom samples were collected from Kenya’s Arabuko–Sokoke and Kakamega National Reserved Forests and identified using morphological and molecular techniques. Chloroform, 70% ethanol, and hot water solvents were used to extract the mycochemical components. Gas chromatography mass spectrometry (GC-MS) was used to analyze the chloroform, 70% ethanol, and hot water extracts of all the species examined. A total of 51 compounds were isolated from all extracts and classified as carboxylic acids, esters, phenols, fatty acids, alcohol, epoxides, aldehydes, fatty aldehydes, isoprenoid lipids, and steroids. Tetracosamethyl-cyclododecasiloxane (18.90%), oleic acid (72.90%), phenol, 2, 6-bis (1, 1-dimethylethyl)-4-methyl-, and methylcarbamate (26.56%) were all found in high concentrations in A. auricular judae, M. xanthopus, T. umkowaani, T. elegans, and T. versicolor, respectively. Fatty acids make up the majority of the compounds isolated from the T. elegans chloroform extract and the T. umkowaani 70% ethanol extract, respectively. Particularly, these fatty acids play crucial roles in the anti-inflammatory, hypocholesterolemic, anticancer, and antibiofilm formation activities. These bioactive elements indicate that the extracts of five wild mushrooms may be reliable sources of secondary metabolites for therapeutic development. Therefore, additional research is required to comprehend the usefulness of these chemicals in many functional areas and to improve the present understanding of macrofungi.

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Section: Introductionmentioning

confidence: 99%

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Gebreyohannes,

Sbhatu

2023

International Journal of Analytical Chemistry

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“…It contains a variety of chemical components, including alkaloids, favonoids, steroids, triterpenoids, and coumar, which have the potential to have positive pharmacological efects with applications in agriculture, medicine, and other felds [31]. According to reports, it has anthelmintic [32], antibacterial [33], anticancer [1], and antiangiogenic properties.…”

Section: Introductionmentioning

confidence: 99%

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Gebreyohannes¹,

Sbhatu²

2023

Preprint

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Mushrooms are unexploited treasures of secondary metabolites. Analysis of the chemical constituents of these mushrooms would be necessary for the assessment of their pharmacological and biological activities. This study aimed at profiling of mycochemical constituents of five wild mushroom extracts thereby understanding their biological and pharmacological properties. Mushrooms were collected from Arabuko-Sokoke and Kakamega National Reserved Forests, Kenya. Specimens were identified by both morphological and molecular methods. Bioactive compounds were extracted using chloroform, 70% ethanol, and hot water solvents. Chloroform, 70% ethanol, and hot water extracts of Auricularia auricula-judae, Microporus xanthopus, Termitomyces umkowaani, Trametes elegans, and Trametes versicolor were determined using gas chromatography and mass spectrometry (GC-MS). From all extracts, a total of fifty-one (51) compounds were identified and grouped into carboxylic acids, esters, phenols, fatty acids, alcohol, epoxides, aldehyde, fatty aldehyde, isoprenoid lipids, and steroid. Of the total compounds, Oleic acid (72.90%) from Trametes elegans was detected abundantly. Most of the compounds obtained from the chloroform extract of Trametes elegans and 70% ethanol extract of T. umkowaani are fatty acids. The identified compounds have revealed many biological and pharmacological activities such as antimicrobial, antioxidant, antimalarial, anti-inflammatory, insecticidal, anti-helminthic, larvicidal, vasodilator, antihypertensive, hepatoprotective, anticancer, antidiabetic, antifertility anti-diuretic, antiasthma, antifouling, anti-dermatophytic, antispasmodic, anti-hypocholesterolemic, nematicide, pesticide, immunostimulant, antiarthritic, and antihistaminic. These fatty acids are particularly playing important roles in the anti-inflammatory, hypocholesterolemic anticancer, and anti-biofilm formation activities. The presence of these bioactive components suggests that the extracts of five wild mushrooms could be good sources of secondary metabolites for drug discovery.

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Chemical Screening, Antioxidant Potential and Antiangiogenic Effect of Microporus Xanthopus (fr.) Kuntze, Ganoderma Orbiforme (fr.) Ryvarden and Polyporus Fasciculatus (pat) lloyd, Medicinal Mushrooms from Gabon

Cited by 2 publications

References 5 publications

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

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