Chemical shift effect predicting lymph node status in rectal cancer using high-resolution MR imaging with node-for-node matched histopathological validation

Zhang, Hongmei; Zhang, Chongda; Zheng, Zhihong; Ye, Feng; Liu, Yuan; Zou, Shuangmei; Zhou, Chunwu

doi:10.1007/s00330-017-4738-7

Cited by 34 publications

(25 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16 This patient with a large T3 MRF+ rectal cancer (yellow arrow in a) presents with a hypointense, highly irregular, intermediate-to-low signal intensity nodule in the mesorectum (red arrows in a and b) that does not interrupt the course of a vein but is irregular enough for us to admit the possibility of an extranodal deposit (mrENTD). The patient also presented with a round, hypointense slightly heterogeneous and slightly irregularly contoured lesion which we believe to be a lymphadenopathy (blue arrow in b) reliable criteria for tumour infiltration [31,32,39]. No reliable criteria exist for nodes smaller than that [31,39].…”

Section: Lymph Node Involvement and Tumour Depositsmentioning

confidence: 96%

“…9) [27][28][29][30]. Normal/reactive lymph nodes on T2-WI MR imaging appear homogeneous in 48 to 88% and with smooth, sharply demarcated borders in 80 to 94% of cases [31,32].…”

Section: The Lymphatic Drainagementioning

confidence: 99%

“…In approximately 70% of cases, they will show a smooth and regular, uninterrupted chemical shift effect on T2-WI in the phase encoding direction, likely the result from the sharp interface between the water-rich subcapsular sinus and the mesorectal fat ( Fig. 10) [32]. Lymph nodes located within the mesorectum, along the inferior and superior rectal vessels, along the inferior mesenteric vessels and along the internal iliac vessels and their branches are considered regional.…”

Section: The Lymphatic Drainagementioning

confidence: 99%

“…9 ) [ 27 – 30 ]. Normal/reactive lymph nodes on T2-WI MR imaging appear homogeneous in 48 to 88% and with smooth, sharply demarcated borders in 80 to 94% of cases [ 31 , 32 ]. In approximately 70% of cases, they will show a smooth and regular, uninterrupted chemical shift effect on T2-WI in the phase encoding direction, likely the result from the sharp interface between the water-rich subcapsular sinus and the mesorectal fat (Fig.…”

Section: Main Textmentioning

confidence: 99%

See 3 more Smart Citations

MRI of rectal cancer—relevant anatomy and staging key points

et al. 2020

View full text Add to dashboard Cite

Rectal cancer has the eighth highest cancer incidence worldwide, and it is increasing in young individuals. However, in countries with a high human development index, mortality is decreasing, which may reflect better patient management, imaging being key. We rely on imaging to establish the great majority of clinical tumour features for therapeutic decision-making, namely tumour location, depth of invasion, lymph node involvement, circumferential resection margin status and extramural venous invasion. Despite major improvements in technique resulting in better image quality, and notwithstanding the dissemination of guidelines and examples of standardised reports, rectal cancer staging is still challenging on the day-today practice, and we believe there are three reasons. First, the normal posterior pelvic compartment anatomy and variants are not common knowledge to radiologists; second, not all rectal cancers fit in review paper models, namely the very early, the very low and the mucinous; and third, the key clinical tumour features may be tricky to analyse. In this review, we discuss the normal anatomy of the rectum and posterior compartment of the pelvis, systematise all rectal cancer staging key points and elaborate on the particularities of early, low and mucinous tumours. We also include our suggested reporting templates and a discussion of its comparison to the reporting templates provided by ESGAR and SAR.

show abstract

Section: Lymph Node Involvement and Tumour Depositsmentioning

confidence: 96%

“…9) [27][28][29][30]. Normal/reactive lymph nodes on T2-WI MR imaging appear homogeneous in 48 to 88% and with smooth, sharply demarcated borders in 80 to 94% of cases [31,32].…”

Section: The Lymphatic Drainagementioning

confidence: 99%

Section: The Lymphatic Drainagementioning

confidence: 99%

Section: Main Textmentioning

confidence: 99%

See 2 more Smart Citations

MRI of rectal cancer—relevant anatomy and staging key points

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Currently, magnetic resonance imaging (MRI) is considered the best non-invasive imaging approach for predicting pCR in patients with rectal cancer treated with nCRT [ 15 – 18 ]. Quantitative measurements of signal intensity obtained using T2-weighted or diffusion weighted MR images (DWI) before and after nCRT, showed to be useful for evaluation of pCR [ 8 , 16 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Morphologic predictors of pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Zhang

Liu

et al. 2017

Oncotarget

Self Cite

View full text Add to dashboard Cite

PurposeTo evaluate the value of morphological parameters that can be obtained conveniently by MRI for predicting pathologically complete response (pCR) in patients with rectal cancer.Materials and MethodsA cohort of 101 patients was examined using MRI before and after Neoadjuvant chemoradiotherapy (nCRT). Morphological parameters including maximum tumor area (MTA), maximum tumor length (MTL) and maximum tumor thickness (MTT), as well as cylindrical approximated tumor volume (CATV), distance to anal verge (DTA), and the reduction rates were evaluated by two experienced readers independently.ResultsPost-nCRT MTA and MTL, reduction rates and pre-nCRT DTA were proved to be significantly different between pCR and non-pCR with the AUCs of 0.672-0.853. The sensitivity and specificity for assessing pCR were 61.1-89.9% and 59.0-80.7% respectively. No significant correlation between pre-nCRT size measurements and pCR was obtained.ConclusionThe convenient morphological measurements may be useful for predicting pCR with moderate sensitivity and specificity. Combining these predictors with the aim of building diagnostic model should be explored.

show abstract

Rationales Staging und Follow-up beim kolorektalen Karzinom

Juchems

Weßling

2019

Radiologe

View full text Add to dashboard Cite

Chemical shift effect predicting lymph node status in rectal cancer using high-resolution MR imaging with node-for-node matched histopathological validation

Cited by 34 publications

References 36 publications

MRI of rectal cancer—relevant anatomy and staging key points

MRI of rectal cancer—relevant anatomy and staging key points

Morphologic predictors of pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Rationales Staging und Follow-up beim kolorektalen Karzinom

Contact Info

Product

Resources

About