Chemical structure and anti-inflammatory effect of polysaccharide extracted from Morinda citrifolia Linn (Noni)

Sousa, Stefany Guimarães; Oliveira, L. A. A. de; Magalhães, Diva de Aguiar; Brito, Tarcísio Vieira de; Batista, Jalles Arruda; Pereira, Cynthia Maria Carvalho; Costa, Mariana de Souza; Mazulo, José Carlos Raposo; Filgueiras, Marcelo de Carvalho; Vasconselos, Daniel Fernando Pereira; Silva, Durcilene Alves da; Barros, Francisco Clark Nogueira; Sombra, Venícios Gonçalves; Freitas, Ana Lúcia Ponte; Paula, Regina C.M. de; Feitosa, Judith Pessoa de Andrade; Barbosa, André Luiz dos Reis

doi:10.1016/j.carbpol.2018.06.042

Cited by 86 publications

(49 citation statements)

References 46 publications

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“…These findings evinced that NRLP might exert its anti-analgesic potency through the central nervous mechanisms. A similar effect has been highlighted for the polysaccharides extracted from Suaeda fruticosa [5] and Morinda citrifolia for example [6].…”

Section: Antinociceptive Activitysupporting

confidence: 73%

“…It has also been reported that the polysaccharides from Apium graveolens have potential anti-inflammatory effects associated with the inhibition of the high production of pro-inflammatory cytokines [69]. The polysaccharides extracted from Caesalpinia ferrea and Azadirachta indica have also been demonstrated to inhibit the edematogenic effect of serotonin, prostaglandin (PGE2), and nitric oxide [6,70,71]. De Oliveira et al [72] have demonstrated that the anti-inflammatory effects of polysaccharides from Sedum dendroideum leaves were attributed to reducing TNF-α and IL1-β secretion.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…Non-steroidal anti-inflammatory drugs (NSAIDs) were commonly demonstrated to reduce inflammatory pains. Due to safety concerns associated with their use, research on new natural products, such as plant-derived polysaccharides, for the management of antinociceptive and anti-inflammatory disorders is of then utmost importance [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Novel Antioxidant, Anti-α-Amylase, Anti-Inflammatory and Antinociceptive Water-Soluble Polysaccharides from the Aerial Part of Nitraria retusa

Rjeibi

Hentati

Feriani

et al. 2019

Foods

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In this paper, water-soluble polysaccharides (named as NRLP) were extracted from Nitraria retusa leaves. The main structural features of NRLP were determined by High-pressure size exclusion chromatography, Fourier transform infrared and Gas Chromatography/Mass Spectrometry-Electronic Impact analysis. The in vitro and in vivo biological potential of NRLP were evaluated by measuring its antioxidant (•OH and DPPH• scavenging, total antioxidant capacity), anti-α-amylase as well as anti-inflammatory and antinociceptive activities in a mice model. NRLP was composed of Rha (33.7%), Gal (18.1%), GalA (15.0%), Glc (13.3%), Ara (13.3%), Xyl (3.8%), and GlcA (2.8%) and showed a Molecular Weight (Mw) of 23.0 kDa and a polydispersity index (PDI) of 1.66. The investigations highlighted a significant antioxidant activity (IC50 = 2.4–2.6 mg/mL) and an inhibition activity against α-amylase (IC50 = 4.55 mg/mL) in a dose-dependent manner. Further, NRLP revealed interesting anti-edematous effects and antinociceptive activities (both > 70%). These results open up new pharmacological prospects for the water-soluble polysaccharides extracted from Nitraria retusa leaves.

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Section: Antinociceptive Activitysupporting

confidence: 73%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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Novel Antioxidant, Anti-α-Amylase, Anti-Inflammatory and Antinociceptive Water-Soluble Polysaccharides from the Aerial Part of Nitraria retusa

Rjeibi

Hentati

Feriani

et al. 2019

Foods

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“…exhibited complete inhibition in carrageenan model (Mckoy et al, ). Polysaccharide‐rich fraction (10 mg/kg) demonstrate significant ( p < .05) reduction in edema (3 h, 0.017 ± 0.006) when compared with positive control (indomethacin, 1 h, 0.038 ± 0.005; Sousa et al, ). The diabetic cases are increasing worldwide; there are numerous reasons (oxidative stress and inflammation) of it (Langenberg & Lotta, ; Ripon, Mahmood, Chowdhury, & Islam, ).…”

Section: Discussionmentioning

confidence: 95%

“…The noni fruit juice prevented inflammation in ovalbumin‐sensitized Brown Norway rats (Dussossoy et al, , ). The polysaccharides‐rich extract, chloroform fraction and damnacanthal from roots of M. citrifolia showed antiinflammatory activity (Okusada et al, ; Sousa et al, ; Yilmazer et al, ). The monotropein from M. officinalis roots contributes to the antinociceptive and antiinflammatory action (Choi et al, ).…”

Section: Pharmacology Of Indian Morinda Speciesmentioning

confidence: 99%

Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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Morinda is a largest genus of Rubiaceae family, and its 11 species are found in India.In India, plant species are known by several common names as great morinda, Indian mulberry, noni, beach mulberry and cheese fruit. Various Morinda products (capsules, tablets, skin products and fruit juices) are available in the market, used by people for treatment of several health complaints. A diversity of phytochemicals including iridoids, flavonoids, flavonoid glycosides, anthraquinones, coumarins, lignanas, noniosides, phenolics and triterpenoids have been reported from Morinda species. Morinda species are used in the treatment of inflammation, cancer, diabetes, psyquiatric disorders, and bacterial and viral infections. The noni fruit juice (Morinda citrifolia) and its products are used clinically in the treatment of cancer, hypertension and cervical spondylosis affecting patients. M. citrifolia fuit juice, with different doses, is used in the maintaining blood pressure and reducing of superoxides, HDL and LDL levels. Similarly, oligosaccharide capsules and tablets of root extract of M. officinalis are recommended as medicine for the treatment of kidney problems and sexual dysfunctions of patients. The toxicological studies revealed that higher doses of fruit juice (4,000 or 5,000 mg/kg) of M. citrifolia for 2 or more months cause toxic effects on liver and kidneys. M. officinalis root extracts (ethanolic and aqueous) are found fully safe during treatment of diseases. A large number of reviews are available on M. citrifolia but very few studies are conducted on other Indian Morinda species. This review reports the comprehensive knowledge on state-wise distribution, botany, ethnomedicinal uses, phytochemistry, pharmacological activities, clinical applications and toxicological evaluations of 11 species of Morinda found in India.

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Anticancer and chemopreventive potential of Morinda citrifolia L. bioactive compounds: A comprehensive update

Kitic,

Miladinovic,

Randjelovic

et al. 2024

Phytotherapy Research

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Morinda citrifolia L., commonly known as Noni, has a longstanding history in traditional medicine for treating various diseases. Recently, there has been an increased focus on exploring Noni extracts and phytoconstituents, particularly for their effectiveness against cancers such as lung, esophageal, liver, and breast cancer, and their potential in cancer chemoprevention. This study aims to provide a comprehensive review of in vitro and in vivo studies assessing Noni's impact on cancer, alongside an exploration of its bioactive compounds. A systematic review was conducted, encompassing a wide range of scientific databases to gather pertinent literature. This review focused on in vitro and in vivo studies, as well as clinical trials that explore the effects of Noni fruit and its phytoconstituents—including anthraquinones, flavonoids, sugar derivatives, and neolignans—on cancer. The search was meticulously structured around specific keywords and criteria to ensure a thorough analysis. The compiled studies highlight Noni's multifaceted role in cancer therapy, showcasing its various bioactive components and their modes of action. This includes mechanisms such as apoptosis induction, cell cycle arrest, antiangiogenesis, and immune system modulation, demonstrating significant anticancer and chemopreventive potential. The findings reinforce Noni's potential as a safe and effective option in cancer prevention and treatment. This review underscores the need for further research into Noni's anticancer properties, with the hope of stimulating additional studies and clinical trials to validate and expand upon these promising findings.

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Chemical structure and anti-inflammatory effect of polysaccharide extracted from Morinda citrifolia Linn (Noni)

Cited by 86 publications

References 46 publications

Novel Antioxidant, Anti-α-Amylase, Anti-Inflammatory and Antinociceptive Water-Soluble Polysaccharides from the Aerial Part of Nitraria retusa

Novel Antioxidant, Anti-α-Amylase, Anti-Inflammatory and Antinociceptive Water-Soluble Polysaccharides from the Aerial Part of Nitraria retusa

Indian Morinda species: A review

Anticancer and chemopreventive potential of Morinda citrifolia L. bioactive compounds: A comprehensive update

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