Chemical Structure, Hypoglycemic Activity, and Mechanism of Action of Selenium Polysaccharides

Duan, Wen-Xia; Yang, Xiaohua; Zhang, Huafeng; Feng, Jing; Zhang, Mengyuan

doi:10.1007/s12011-021-03035-z

Cited by 27 publications

(22 citation statements)

References 69 publications

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Section: Introductionmentioning

confidence: 99%

“…In ancient Chinese medicinal documents, C. morifolium was recorded as a top-grade edible herb, which is helpful to "qi," blood and longevity of humans (Chu et al, 2014;Zhang et al, 2018). To date, a large number of papers have been published to deal with separation and purification of volatile oil, phenols (e.g., phenolic acids and flavonoids), and polysaccharides with health benefits such as antioxidant, anti-inflammatory, and antitumor activities (Duan et al, 2022;Yang, Nuerbiye, et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Edible medicinal plants usually contain a number of phytochemicals and nutrients such as trace elements, which are closely associated with their pharmacological properties (Ajagun‐Ogunleye & Ebuehi, 2020;Duan et al, 2022; Yao et al, 2021; Zhang et al, 2018). Selenium (Se) is an essential micronutrient for both humans and animals owing to its crucial physiological functions (Duan et al, 2022; Yao et al, 2021; Zhang et al, 2018). The bioactivities of Se are usually related to Se‐binding isolates such as Se‐containing proteins, Se‐containing polyphenols, and other Se‐containing components from Se‐enriched foods (Chafik et al, 2019; Duan et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Selenium (Se) is an essential micronutrient for both humans and animals owing to its crucial physiological functions (Duan et al, 2022; Yao et al, 2021; Zhang et al, 2018). The bioactivities of Se are usually related to Se‐binding isolates such as Se‐containing proteins, Se‐containing polyphenols, and other Se‐containing components from Se‐enriched foods (Chafik et al, 2019; Duan et al, 2022). In many cases, Se‐binding isolates can be absorbed and utilized by organisms, which displayed some activities such as antioxidant, immunomodulatory, and antitumor properties (Chafik et al, 2019; Li et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…In ancient Chinese medicinal documents, C. morifolium was recorded as a top‐grade edible herb, which is helpful to “qi,” blood and longevity of humans (Chu et al, 2014; Zhang et al, 2018). To date, a large number of papers have been published to deal with separation and purification of volatile oil, phenols (e.g., phenolic acids and flavonoids), and polysaccharides with health benefits such as antioxidant, anti‐inflammatory, and antitumor activities (Duan et al, 2022; Yang, Nuerbiye, et al, 2017). In our laboratory, an accurate, precise, sensitive, and safe method was developed for quantitative assay of selenium, by which Se contents in C. morifolium samples collected from 10 cities of China (e.g., Ankang City) were determined (Zhang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Se‐enriched Chrysanthemum morifolium on lifespan and antioxidant defense‐related gene expression of Drosophila melanogaster model

Feng

Xiao

et al. 2022

Journal of Food Biochemistry

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Chrysanthemum morifolium is a well‐known edible medicinal plant in Asia and some other regions. Content of selenium in Se‐enriched C. morifolium (SeCM) is significantly higher than that in traditional C. morifolium (non‐Se‐enriched C. morifolium, TCM). In order to understand health effects of SeCM, its chemical composition, lifespan‐prolonging activities, and impacts on antioxidant defense‐related gene expressions of model organism D. melanogaster were systematically studied. A total of eight phenols, including luteolin‐7‐O‐glucoside, linarin, luteolin, apigenin, diosmetin, acacetin, 3‐caffeoylquinic acid and 4,5‐dicaffeoylquinic acid, were identified in SeCM extract. Compared with TCM, SeCM exhibited superior antioxidant properties. Intake of SeCM dramatically reduced malondialdehyde level and increased activities of endogenous antioxidant enzymes in fruit flies. SeCM was able to upregulate gene expressions of Cu/Zn‐superoxide dismutase, Mn‐superoxide dismutase and hydrogen peroxide catalase, and extend lifespans of fruit flies. Comparatively high antioxidant capacities and lifespan‐prolonging activities of SeCM might be attributed to its abundant phenols and selenium, which probably ameliorated accumulation of free radicals and susceptibility to oxidative stress. These findings provide clues on further exploitation and utilization of Se‐enriched C. morifolium. Practical applications Chrysanthemum morifolium has been used for nutraceutical and curative purposes in China for thousands of years. Se‐enriched C. morifolium typically contains more selenium than traditional C. morifolium, and is widely consumed in Asia and some other regions. Selenium is an essential micronutrient for humans, and selenium deficiency may result in several diseases such as myocardial infarction. SeCM is one of important selenium supplements. In this study, SeCM was found to upregulate gene expressions of Cu/Zn‐superoxide dismutase, Mn‐superoxide dismutase, and hydrogen peroxide catalase, and extend lifespans of experimental animals. These results provide supporting information for developing SeCM‐based functional foods with distinct health benefits.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Se‐enriched Chrysanthemum morifolium on lifespan and antioxidant defense‐related gene expression of Drosophila melanogaster model

Feng

Xiao

et al. 2022

Journal of Food Biochemistry

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Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus

Liu,

Zheng,

Wang

et al. 2024

Anim Models and Exp Med

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In traditional Chinese medicine (TCM), based on various pathogenic symptoms and the ‘golden chamber’ medical text, Huangdi Neijing, diabetes mellitus falls under the category ‘collateral disease’. TCM, with its wealth of experience, has been treating diabetes for over two millennia. Different antidiabetic Chinese herbal medicines reduce blood sugar, with their effective ingredients exerting unique advantages. As well as a glucose lowering effect, TCM also regulates bodily functions to prevent diabetes associated complications, with reduced side effects compared to western synthetic drugs. Chinese herbal medicine is usually composed of polysaccharides, saponins, alkaloids, flavonoids, and terpenoids. These active ingredients reduce blood sugar via various mechanism of actions that include boosting endogenous insulin secretion, enhancing insulin sensitivity and adjusting key enzyme activity and scavenging free radicals. These actions regulate glycolipid metabolism in the body, eventually achieving the goal of normalizing blood glucose. Using different animal models, a number of molecular markers are available for the detection of diabetes induction and the molecular pathology of the disease is becoming clearer. Nonetheless, there is a dearth of scientific data about the pharmacology, dose‐effect relationship, and structure–activity relationship of TCM and its constituents. Further research into the efficacy, toxicity and mode of action of TCM, using different metabolic and molecular markers, is key to developing novel TCM antidiabetic formulations.

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Structural characterization, hypoglycemic and immune-enhancing activities of a polysaccharide from Oenanthe javanica

Cui,

Cheng,

Shen

et al. 2023

Food Measure

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Chemical Structure, Hypoglycemic Activity, and Mechanism of Action of Selenium Polysaccharides

Cited by 27 publications

References 69 publications

Effects of Se‐enriched Chrysanthemum morifolium on lifespan and antioxidant defense‐related gene expression of Drosophila melanogaster model

Effects of Se‐enriched Chrysanthemum morifolium on lifespan and antioxidant defense‐related gene expression of Drosophila melanogaster model

Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus

Structural characterization, hypoglycemic and immune-enhancing activities of a polysaccharide from Oenanthe javanica

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