Chemical structures and induction of cell death via heat shock protein inhibition of the prenylated phloroglucinol derivatives isolated from Hypericum erectum

Μatsumoto, Takahiro; Imahori, Daisuke; Ohnishi, Erika; Okayama, Masaya; Kitagawa, Takahiro; Ohta, Tomoe; Yoshida, Tatsusada; Kojima, Naoto; Yamashita, Masayuki; Watanabe, Tetsushi

doi:10.1016/j.fitote.2021.105097

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…The results revealed that these compounds did not inhibit the expression of HSP90 but inhibited that of HSP105. HSP105 expression was inhibited by these compounds [8, 9]. Their results suggest that these five compounds increase the sensitivity of HeLa cells to adriamycin via suppressing HSP105 expression.…”

Section: Search For Small‐molecule Compounds From Medicinal Plants Th...mentioning

confidence: 99%

Conference report: Third annual young researcher forum of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine

Yoshino

Yokogawa

Nakamichi

et al. 2023

Traditional & Kampo Medicine

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Four young researchers presented their studies in the field of traditional Japanese herbal medicine (Wakan‐yaku) at the third annual young researcher forum entitled “Respecting and Breaking Traditions,” held 1 week before the 2022 annual meeting of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine. Dr. Yokogawa presented her research focusing on the mechanism of the Ayurveda drug‐eluting string, Kshara Sutra, in treating anal fistulas, reporting on its effects on the anal tissue in an anal fistula rat model and its antibacterial activity against Escherichia coli and Staphylococcus aureus, the causative organisms of anal fistulas. Mr. Nakamichi presented his research focusing on the relationship between the efficacy of Kampo medicines with anti‐obesity effects and intestinal microbiota composition. His results partially revealed that bofutsushosan and boiogito affect lipid metabolism in mice and correlate with the intestinal microbiota composition. Dr. Manse reported the anti‐inflammatory activity of diterpenoid components in Enmei‐so (Isodonis Herba), revealing its novel inhibitory activity on nitric oxide released from activated macrophages and on inflammatory cytokines, and identified active components contributing to the inhibition and the mechanism of action. Mr. Yoshikawa reported the anticancer activity of small molecular compounds isolated from the medicinal plants, Valeriana fauriei and Hypericum erectum. His results suggest that five compounds may increase the sensitivity of human cervical carcinoma cells to adriamycin via HSP105 expression suppression. The event was conducted online, and included 78 participants. We intend to hold and improve this forum in 2023 and the future.

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Section: Search For Small‐molecule Compounds From Medicinal Plants Th...mentioning

confidence: 99%

Conference report: Third annual young researcher forum of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine

Yoshino

Yokogawa

Nakamichi

et al. 2023

Traditional & Kampo Medicine

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“…Previously, we reported that the inhibitors of P-gp and HSP enhance the cytotoxicity of ADR. 8,25,26 We further evaluated the effects of isolated compounds (1−11) on the cytotoxicity of ADR using time-lapse cell imaging analysis on HeLa cells. In this study, we counted the number of mitotic entry cells and dead cells treated with ADR (0.5, 1.0, or 2.0 g/mL), isolated compounds (1−11, 60 M), and isolated compounds with ADR (1.0 g/mL).…”

Section: Figure 1 the Chemical Structures Of The Isolated Compounds F...mentioning

confidence: 99%

Chemical Structures and Cell Death Inducing Activities of Constituents Isolated from Hibiscus tiliaceus

Μatsumoto¹,

Watanabe²,

Kitagawa³

et al. 2022

HETEROCYCLES

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A new coumarin glycoside hibiscuscoumarin (1) was obtained with ten known compounds including seguinoside K (7) from the stems and twigs of Hibiscus tiliaceus. The structure of hibiscuscoumarin (1) was elucidated based on the chemical/physicochemical evidence. The cell death-inducing activities of the isolated compounds with or without Adriamycin (ADR) were observed using time-lapse cell imaging. The isolated compounds did not affect the number of mitotic entry cells and dead cells. Otherwise, the treatment of cells with seguinoside K (7) significantly increased the number of dead cells induced by ADR.

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“…When cells are exposed to different types of stressors, including heat or cold ( Hanafi et al, 2022 ), pathogens ( Jariyapan et al, 2021 ), transport ( Zheng et al, 2021 ), or chemicals ( Μatsumoto et al, 2022 ), the levels of HSPs undergo changes to maintain the stability of the intracellular environment. HSPs bind to various proteins in the body to safeguard essential physiological processes.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic study of heat shock protein 60-mediated apoptosis in DF-1 cells

Li,

Cao,

2024

Poultry Science

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Chemical structures and induction of cell death via heat shock protein inhibition of the prenylated phloroglucinol derivatives isolated from Hypericum erectum

Cited by 9 publications

References 26 publications

Conference report: Third annual young researcher forum of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine

Conference report: Third annual young researcher forum of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine

Chemical Structures and Cell Death Inducing Activities of Constituents Isolated from Hibiscus tiliaceus

Mechanistic study of heat shock protein 60-mediated apoptosis in DF-1 cells

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