Chemical Studies on <i>Taxus canadensis</i>

Li, Yong; Qin, Fang; Wang, Siming; Guo, Ruixia; Zhang, Yue‐Feng; Gu, Yu‐Cheng; Shi, Qing

doi:10.1002/cbdv.201200032

Cited by 13 publications

(5 citation statements)

References 63 publications

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“…A review listing their isolation and discussing their chemistry has appeared. 158 A short enantioselective synthesis of a taxol ring A fragment has been reported. 159 Diterpenoids of the lathyrane, tigliane, ingenane, daphnane and related carbon skeletons possess a range of biological activities, including interaction with protein kinase C which plays a role in regulating cellular growth and differentiation.…”

Section: Macrocyclic Diterpenoids and Their Cyclization Productsmentioning

confidence: 99%

Diterpenoids of terrestrial origin

Hanson

2015

Nat. Prod. Rep.

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Section: Macrocyclic Diterpenoids and Their Cyclization Productsmentioning

confidence: 99%

Diterpenoids of terrestrial origin

Hanson

2015

Nat. Prod. Rep.

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“…Other than paclitaxel, numerous different taxoids such as 10-deacetylbaccatin III (10-DAB III), baccatin III (BAC-III), cephalomannine, taxinine M, 10-deacetyltaxol (10-DAT), and 5-epi-canadensene have been recognized and isolated from T. yunnanensis. − Paclitaxel alongside semisynthetic drugs from precursor BAC-III and 10-DAB III has been used for the treatment of many cancers including breast cancer, , ovarian carcinomas, skin cancer, and nonsmall-cell lung cancer T.…”

Section: Introductionmentioning

confidence: 99%

Comparative Transcriptome Analysis Revealed the Tissue-Specific Accumulations of Taxanes among Three Experimental Lines of Taxus yunnanensis

Mubeen

Li²,

Qiao-ming³

et al. 2018

J. Agric. Food Chem.

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Taxus yunnanensis (Yew) is known for natural anticancer metabolite paclitaxel (Taxol) and its biosynthesis pathway in yew species still needs to be completely elucidated. In the current study, productions of paclitaxel and 10-DAB III from three different tissues (needle, branch, and root) of T. yunnanensis wild type (WT) and two new cultivars Zhongda-1 (Zd1) and Zhongda-2 (Zd2) were determined, and significant tissue differences in contents of the taxanes were observed among the three experimental lines. The much higher 10-DAB III and lower paclitaxel contents in needle of Zd2 when compared with that of Zd1 indicated the low conversion from 10-DAB III to paclitaxel in the needle of Zd2. In order to uncover the mechanisms of the tissue-specific biosynthesis of the taxanes, transcriptome analysis of cultivar Zd2 was conducted, and the previously reported transcriptome data of Zd1 and WT were used to perform a comparison. The enhancement of TDAT and T10βH side biosynthetic pathway in roots of Zd2 in early taxane synthesis might lead to the biosynthesis of other toxoids, while the preference of T13αH route in the needle and branch of Zd2 was mainly responsible for the tissue-specific reinforced biosynthesis of 10-DAB III and paclitaxel in Zd2. Different from Zd1, the tissue-specific pattern of paclitaxel biosynthesis genes in Zd2 was similar to WT. However, the lower transcript abundance of final steps genes (TBT, DBAT, BAPT, and DBTNBT) of the paclitaxel biosynthesis pathway in Zd2 than in Zd1 might further promote 10-DAB III accumulation in Zd2.

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“…In particular, novel studies are needed to define the therapeutic window where compounds could be most effective with the least in vivo toxicity. CM is a taxane isolated from the needles of Taxus canadensis [21][22][23]. The activity of taxanes as anticancer agents has a long history and is well documented.…”

Section: Discussionmentioning

confidence: 99%

A Drug Screening Revealed Novel Potential Agents against Malignant Pleural Mesothelioma

Dell’Anno

Melani

Martin

et al. 2022

Cancers

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The lack of effective therapies remains one of the main challenges for malignant pleural mesothelioma (MPM). In this perspective, drug repositioning could accelerate the identification of novel treatments. We screened 1170 FDA-approved drugs on a SV40-immortalized mesothelial (MeT-5A) and five MPM (Mero-14, Mero-25, IST-Mes2, NCI-H28 and MSTO-211H) cell lines. Biological assays were carried out for 41 drugs, showing the highest cytotoxicity and for whom there were a complete lack of published literature in MPM. Cytotoxicity and caspase activation were evaluated with commercially available kits and cell proliferation was assayed using MTT assay and by clonogenic activity with standard protocols. Moreover, the five most effective drugs were further evaluated on patient-derived primary MPM cell lines. The most active molecules were cephalomannine, ouabain, alexidine, thonzonium bromide, and emetine. Except for alexidine, these drugs inhibited the clonogenic ability and caspase activation in all cancer lines tested. The proliferation was inhibited also on an extended panel of cell lines, including primary MPM cells. Thus, we suggest that cephalomannine, ouabain, thonzonium bromide, and emetine could represent novel candidates to be repurposed for improving the arsenal of therapeutic weapons in the fight against MPM.

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Chemical Studies on Taxus canadensis

Cited by 13 publications

References 63 publications

Diterpenoids of terrestrial origin

Diterpenoids of terrestrial origin

Comparative Transcriptome Analysis Revealed the Tissue-Specific Accumulations of Taxanes among Three Experimental Lines of Taxus yunnanensis

A Drug Screening Revealed Novel Potential Agents against Malignant Pleural Mesothelioma

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