Chemical Study and Antimalarial, Antioxidant, and Anticancer Activities ofMelaleuca armillaris(Sol Ex Gateau) Sm Essential Oil

Abstract

This study investigated the chemical composition (by using gas chromatography/flame ionization detection and gas chromatography/mass spectrometry, an antioxidant [1,1-diphenyl-2-picrylhydrazyl] [DPPH] radical-scavenging assay, and a 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonate [ABTS] radical cation-scavenging assay) and the antimalarial and cytotoxic activities of essential oil extracted from leaves of Melaleuca armillaris. Thirty-two components representing more than 98% of the total composition of the essential oil were identified. The main components were 1,8-cineole (85.8%), camphene (5.05%), and α-pinene (1.95%). The antioxidant activity by ABTS assay showed a mean (± standard deviation) 50% inhibitory concentration (IC(50)) value of 247.3 ± 3.9 mg/L, and the DPPH assay yielded an IC(50) value of 2183.6 ± 44.3 mg/L. The antimalarial study indicated that the essential oil had mild activity against the chloroquine-resistant Plasmodium falciparum FcB1 strain (IC(50), 27 ± 2 mg/L). The cytotoxic activity of this essential oil was tested against MCF7 human breast cancer cells and was found to be high (IC(50), 12 ± 1 mg/L).

Chemical Composition and Biological Activities of the Essential Oils from Three Melaleuca Species Grown in Tunisia

“…Other compounds, in a lesser amount, are dihydrocarveol (9.0%) and α-terpineol (7.7%), both oxygenated monoterpenoids. In the literature, Chabir and coworkers [8,9] reported 1,8-cineole (85.8%) as the most abundant compound in M. armillaris. The major compound in the essential oil of M. styphelioides was methyl eugenol (91.1%), a phenolic compound.…”

“…Literature reports about M. armillaris remain scarce. GC/MS investigations of its essential oil revealed the presence of 1,8-cineole as the main component [8–12]. Only little information could be found in the literature about the composition of Melaleuca styphelioides Sm.…”

Pleiotropic Chemodiversity in Extracts and Essential Oil of Melaleuca viminalis and Melaleuca armillaris of Myrtaceae Family

“…24-26 Some of them constitute effective alternatives or complements to synthetic compounds of the chemical industry, without exerting the secondary effects of the latter. 27 As reported earlier, essential oils of the Myrtaceae family are Evaluation of activities against various in vitro biological parameters indicated that the methanol extract, acetone extract and essential oil of M. viminalis possess the highest scavenging activities, followed by the chloroform and ethyl acetate extracts; 3 Salem et al 35 and Chabir et al 9 The antibacterial activity of essential oils and extracts of both M. viminalis and M. armillaris plants were evaluated and found to be effective against the tested bacteria. The highest antimicrobial activity was observed on Gram-positive bacteria.…”

Efecto antimicrobiano de la combinación de cloxacilina con aceite esencial de Melaleuca armillaris frente a Staphylococcus aureus

“…más ampliamente cultivadas, cuyo AE, aún poco estudiado, debido a la presencia de 1,8-cineol entre sus principales componentes, se transforma en una alternativa terapéutica con prometedoras acciones farmacológicas (Chabir et al, 2011). Se encontró actividad inhibitoria, in vitro, frente a especies bacterianas como Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli y Pseudomonas aeuriginosa (Amri et al, 2012).…”