Chemical Suppression of Steroidogenesis

Mineralocorticoid Receptor Antagonists for the Treatment of Hypertension and Diabetic Nephropathy

“…It is known that spironolactone can bind to and inhibit steroidogenic cytochrome P450 enzymes. 18 It has recently been demonstrated that in human adrenocortical H295R cells, spironolactone inhibited steroid production while eplerenone had no effect on production of aldosterone or cortisol in this system. Furthermore, the metabolic instability of steroids in the presence of CYPs can affect the magnitude and duration of action and can alter their pharmacological and toxicological profiles in relevant organs.…”

“…Another complicating factor with the use of steroid based agents is the potential for inhibition of the steroidogenesis pathway. It is known that spironolactone can bind to and inhibit steroidogenic cytochrome P450 enzymes . It has recently been demonstrated that in human adrenocortical H295R cells, spironolactone inhibited steroid production while eplerenone had no effect on production of aldosterone or cortisol in this system.…”

The Effects of Chemicals on Mammalian Fertility

“…The production of steroid hormones is a complex process requiring several steps that can be sensitive to chemical insult (40).…”