Chemical transformations of chlorophyll and its application in the design of a new generation of environmentally safe dyes

Berezin, B. D.; Rumyantseva, S. V.; Moryganov, A. P.; Березин, М. Б.

doi:10.1070/rc2004v073n02abeh000773

Cited by 16 publications

(4 citation statements)

References 41 publications

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“…Накопление данных об особенностях поведения и специфики свойств этих соединений позволило найти области их применения и, в первую очередь, биопорфиринов. [5] Во всех биологически важных системах фотосинтеза и дыхания порфирин не является изолированной единицей, а функционирует только в составе сложных молекулярных комплексов с высокомолекулярными и малыми молекулами. Строго определенная комбинация иона металла, макрогетероциклического лиганда и специфического окружения биополимера является определяющим фактором для проявления биологической активности и селективности этих соединений в живых организмах.…”

Section: порфирины Porphyrinsunclassified

Synthesis of Molecular Synthons for Porphyrinpolymers

Агеева¹,

Сырбу²,

Койфман³

2009

MHC

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Peculiarities of the unique structure of porphyrins, possibilities of their peripheral functionalization, ability of metal complexes to extracoordination allow to use them for inclusion in porphyrin-polymer systems in order to endow them with specific properties, determined by tetrapyrrole macrocyclic compounds and their complexes. Porphyrins and their analogues being immobilised on a polymer carrier not only preserve their useful properties, but even strengthen them due to cooperative interactions in polymer chains, separation of active centres, increase of stability of tetrapyrrole fragments This review systematise methods of synthesis of meso-phenyl substituted porphyrins which can be used for fastening on a polymer-carrier. The general approaches to functionalization of porphyrin monomers and their immobilization on synthetic polymers by macromolecular reactions and copolymerization are considered. Strategy of porphyrin-polymer syntheses is based on the previoiusly obtained regularities of mutual influence of the structure of tetrapyrrolic macroheterocycles and polymer-carriers and their ability to self-organization.

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Section: порфирины Porphyrinsunclassified

Synthesis of Molecular Synthons for Porphyrinpolymers

Агеева¹,

Сырбу²,

Койфман³

2009

MHC

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“…Due to its unique properties, Chl has found wide application for various purposes: as a food additive (E140), a dye, in photochemical and electrochemical catalysis, as well as for the generation of singlet molecular oxygen during PDT [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of chlorophyll polymeric form against test cultures S. aureus and E. coli

Gruznov,

Gruznova,

Lobanov

et al. 2024

BIO Web Conf.

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The increase in the number of microorganism strains with resistance to anti-bacterial and disinfecting agents is getting more and more prevalent and has become an issue when treating the human and animals diseases and carrying out measures for disinfection treatment. This problem can be solved by using photodynamic and light-independent therapy. In both areas, metalloporphyrins have been successfully used for many years. One of the most famous representatives of porphyrins is chlorophyll (Chl). This work aims to develop of Chl polymeric form by incorporation in poly(lactic acid) (PLA) and study its inhibitory effect against Staphylococcus aureus and Escherichia coli, which are known as contaminants of the mucous and skin epithelium of humans and animals. The preparation method of Chl polymeric form is presented. The degree of Chl incorporation into PLA was more than 98%. The assessment of antimicrobial activity was carried out by measuring the inhibition zone diameters after bacterial incubation for 24–96 h. It was shown that Chl and Chl-PLA at a dosage of 75 µg inhibited S. aureus significantly. The exclusively bacteriostatic effect on E. coli was observed. These results can be used in the development of dosage forms and disinfectants.

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“…The first information about Chl dates back to 1817, when two French chemists Peltier and Quantou published the work entitled "Notes on the Green Matter of Leaves". Due to its special chemical, photochemical and photophysical properties, Chl has found wide application in the photoconversion of solar energy, in semiconductor technology, in photochemical and electrochemical catalysis, for the generation of singlet molecular oxygen, for thermal and photostabilization of fats and polymers, and also as a dye in textiles, paint and varnish, food and other industries [7].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial properties of chlorophyll and hemin incorporated into the polymeric matrix of poly-N-vinylpyrrolidone

Gruznov,

Gruznova,

Chesnokova

et al. 2024

BIO Web Conf.

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The increase in the number of antibiotic-resistant strains of microorganisms is becoming more widespread. Metalloporphyrins are promising and modern antimicrobial agents. The most well-known representatives of metalloporphyrins are chlorophyll (Chl) and hemin. This paper presents the results of studies on the effectiveness of Chl and hemin complexes with poly-N -vinylpyrrolidone (PVP) as an antimicrobial agent against Staphylococcus aureus and Escherichia coli. The method for preparing polymeric forms of Chl and hemin is presented. The binding constants of these substances to the polymer were calculated, which were 0.5×105 L/mol for Chl and 3.3×104 L/mol for hemin. Experimental data on the release of substances from the polymeric matrix were obtained. It was found that the complete release of Chl from PVP was observed after 13 h, and hemin – after 10 h. The data on the comparative antimicrobial effect of substances in free and polymeric form were obtained in a microbiological test. Further these results can be used in the development of medicines against microbial infections.

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Chemical transformations of chlorophyll and its application in the design of a new generation of environmentally safe dyes

Cited by 16 publications

References 41 publications

Synthesis of Molecular Synthons for Porphyrinpolymers

Synthesis of Molecular Synthons for Porphyrinpolymers

Antibacterial activity of chlorophyll polymeric form against test cultures S. aureus and E. coli

Antimicrobial properties of chlorophyll and hemin incorporated into the polymeric matrix of poly-N-vinylpyrrolidone

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