1996
DOI: 10.1002/eji.1830260827
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Chemically induced sarcomas from nude mice are more immunogenic than similar sarcomas from congenic normal mice

Abstract: To detect possible differences in immunogenicity between tumors induced in T cell-deficient mice and phenotypically normal congenic mice, 16 sarcomas, 8 having developed in nude BALB/c mice and 8 having developed in congenic normal (nu/+) mice, were transplanted to normal BALB/c recipients and the rates of rejection or acceptance were registered. The 16 tumors were chosen randomly from a panel of 39 sarcomas induced with 0.5% or 0.1% 3-methylcholanthrene and maintained as cell lines in culture. Out of the tumo… Show more

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Cited by 68 publications
(52 citation statements)
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“…However, the scid tumours had a notably longer latency time in scid mice than did non-scid tumours, the latencies being on average 25 days and 12 days, respectively. A similar difference was observed between tumours from immunocompetent and immunodeficient mice in the aforementioned Balb/c transplantation experiment [18]. We have no immediate explanation for this, but it should be investigated whether it is owing to non-adaptive immunological responses that might be stronger in the immunodeficient mice.…”
Section: Discussionsupporting
confidence: 62%
See 3 more Smart Citations
“…However, the scid tumours had a notably longer latency time in scid mice than did non-scid tumours, the latencies being on average 25 days and 12 days, respectively. A similar difference was observed between tumours from immunocompetent and immunodeficient mice in the aforementioned Balb/c transplantation experiment [18]. We have no immediate explanation for this, but it should be investigated whether it is owing to non-adaptive immunological responses that might be stronger in the immunodeficient mice.…”
Section: Discussionsupporting
confidence: 62%
“…1). In a previous paper [18] we published the results of a similar experimental setup in athymic (nu/nu) Balb/c and congenic immunocompetent (nu/+) mice, and there we also did not find such a difference in MHC class I expression. However, both experiments clearly demonstrate that tumours induced in an immunocompetent host are accepted much more readily by immunocompetent recipients than are tumours induced in immunodeficient hosts.…”
Section: Discussionsupporting
confidence: 50%
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“…They compared the immunogenicity of induced tumours from immunodeficient mice and congenic mice with a normal immune system. The first study used athymic nude BALB/c mice as a model of immunodeficiency (Svane et al, 1996), the second study used C.B-17 mice with severe combined immune deficiency (SCID) (Engel et al, 1997). In both studies, mice were treated with a potent carcinogen, MCA, and any tumours which developed were recovered.…”
Section: Evidence For a Process Of Immune Selectionmentioning
confidence: 99%