2024
DOI: 10.1101/2024.02.27.582168
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Chemically induced senescence prompts functional changes in human microglia-like cells

S. Armanville,
C. Tocco,
Z. Haj Mohamad
et al.

Abstract: In response to various stressors, cells can enter a state called cellular senescence which is characterized by irreversible cell cycle arrest and a senescence-associated secretory phenotype (SASP). The progressive accumulation of senescent glial cells in the central nervous system (CNS) with aging suggests a potential role for senescence as driver of aging and inflammation in the brain. As the main immune cell population residing in the CNS, microglia are thought to play a pivotal role in the progression of ag… Show more

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