Chemically or surgically induced thyroid dysfunction altered gut microbiota in rat models

Shin, Na Rae; Bose, Shambhunath; Wang, Jinghua; Nam, Young-Do; Song, Eun-Ji; Lim, Dong‐Woo; Kim, Hee-Bok; Lim, Yun-Sung; Choi, Han Seok; Kim, Hojun

doi:10.1096/fj.201903091rr

Cited by 16 publications

(14 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies in humans showed that hyperthyroid patients had significant enrichments in pathogenic bacteria such as Enterobacteriaceae and Clostridium in the gut in comparison with a healthy group (Zhou et al, 2014), while hypothyroidism was accompanied by a modest intestinal bacterial overgrowth (Lauritano et al, 2007;Zhao et al, 2018). Both rat (Shin et al, 2020) and gerbil models (in the present study) of thyroid dysfunction revealed that profile of gut microbiota varied with different thyroid functional status. We also observed that the hyperthyroid gerbils showed an increase in pathogenic bacteria, such as Rikenella, Helicobacter, Staphylococcus and Veillonella, which have been reported as causes of serious infections and inflammation (Alkadhi et al, 2014).…”

Section: Thyroid Hormones Shaped Metabolic Phenotype and Microbiota Diversitymentioning

confidence: 48%

Cecal microbial transplantation attenuates hyperthyroid‐induced thermogenesis in Mongolian gerbils

Khakisahneh

Zhang

Nouri

et al. 2021

Microbial Biotechnology

View full text Add to dashboard Cite

Endothermic mammals have a high energy cost to maintain a stable and high body temperature (T b , around 37°C). Thyroid hormones are a major regulator for energy metabolism and T b . The gut microbiota is involved in modulating host energy metabolism. However, whether the interaction between the gut microbiota and thyroid hormones is involved in metabolic and thermal regulations is unclear. We hypothesized that thyroid hormones via an interaction with gut microbiota orchestrate host thermogenesis and T b . L-thyroxine-induced hyperthyroid Mongolian gerbils (Meriones unguiculatus) increased resting metabolic rate (RMR) and T b , whereas Methimazoleinduced hypothyroid animals decreased RMR. Both hypothyroid and hyperthyroid animals differed significantly in faecal bacterial community. Hyperthyroidism increased the relative abundance of pathogenic bacteria, such as Helicobacter and Rikenella, and decreased abundance of beneficial bacteria Butyricimonas and Parabacteroides, accompanied by reduced total bile acids and short-chain fatty acids. Furthermore, the hyperthyroid gerbils transplanted with the microbiota from control donors increased type 2 deiodinase (DIO2) expression in the liver and showed a greater rate of decline of both serum T3 and T4 levels and, consequently, a more rapid recovery of normal RMR and T b . These findings indicate that thyroid hormones regulate thermogenesis depending on gut microbiota and colonization with normal microbiota by caecal microbial transplantation attenuates hyperthyroid-induced thermogenesis. This work reveals the functional consequences of the gut microbiota-thyroid axis in controlling host metabolic physiology and T b in endotherms.

show abstract

Section: Thyroid Hormones Shaped Metabolic Phenotype and Microbiota Diversitymentioning

confidence: 48%

Cecal microbial transplantation attenuates hyperthyroid‐induced thermogenesis in Mongolian gerbils

Khakisahneh

Zhang

Nouri

et al. 2021

Microbial Biotechnology

View full text Add to dashboard Cite

show abstract

“…The effects of MMI/PTU on microbiota were also measured in female adult SD rats (Sun et al, 2020). ATDs increased the alpha-diversity, different from the results in female rats (Shin et al, 2020). The ATD group had more Bacteroidetes, Proteobacteria, and Spirochaetae, but fewer The microbial dysbiosis index (MDI) increased after ATD treatment, indicating that the gut microbiota structure was disturbed in the treatment group.…”

Section: Antithyroid Drugs and Gut Microbiotamentioning

confidence: 73%

“…Methimazole (MMI) and propylthiouracil (PTU) are the commonly used antithyroid drugs (ATDs). ATD can change the gut microbiota structure in wild-type adult rats ( Shin et al., 2020 ; Sun et al., 2020 ) and GD patients ( Sun et al., 2020 ; Chen et al., 2021 ; Huo et al., 2021 ).…”

Section: The Effects On the Gut Microbiota Of Therapeutic Agents For Gd/gomentioning

confidence: 99%

See 1 more Smart Citation

The Role of the Microbiota in Graves’ Disease and Graves’ Orbitopathy

Hou

Tang²,

Chen³

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Graves‘ disease (GD) is a clinical syndrome with an enlarged and overactive thyroid gland, an accelerated heart rate, Graves’ orbitopathy (GO), and pretibial myxedema (PTM). GO is the most common extrathyroidal complication of GD. GD/GO has a significant negative impact on the quality of life. GD is the most common systemic autoimmune disorder, mediated by autoantibodies to the thyroid-stimulating hormone receptor (TSHR). It is generally accepted that GD/GO results from complex interactions between genetic and environmental factors that lead to the loss of immune tolerance to thyroid antigens. However, the exact mechanism is still elusive. Systematic investigations into GD/GO animal models and clinical patients have provided important new insight into these disorders during the past 4 years. These studies suggested that gut microbiota may play an essential role in the pathogenesis of GD/GO. Antibiotic vancomycin can reduce disease severity, but fecal material transfer (FMT) from GD/GO patients exaggerates the disease in GD/GO mouse models. There are significant differences in microbiota composition between GD/GO patients and healthy controls. Lactobacillus, Prevotella, and Veillonella often increase in GD patients. The commonly used therapeutic agents for GD/GO can also affect the gut microbiota. Antigenic mimicry and the imbalance of T helper 17 cells (Th17)/regulatory T cells (Tregs) are the primary mechanisms proposed for dysbiosis in GD/GO. Interventions including antibiotics, probiotics, and diet modification that modulate the gut microbiota have been actively investigated in preclinical models and, to some extent, in clinical settings, such as probiotics (Bifidobacterium longum) and selenium supplements. Future studies will reveal molecular pathways linking gut and thyroid functions and how they impact orbital autoimmunity. Microbiota-targeting therapeutics will likely be an essential strategy in managing GD/GO in the coming years.

show abstract

“…In recent years, numerous studies have shed light on the crucial role of gut microbiota on multiple metabolic and autoimmune diseases, such as diabetes mellitus, lupus, Alzheimer's disease, obesity, and so on [ 13 , 14 ]. It is well known that the thyroid hormone could influence the gastrointestinal structure and function, especially motility of the gut; meanwhile, a healthy gut microbiota also has beneficial effects on thyroid function [ 15 – 17 ]. Although there are several studies that explore the relationship between gut microbiota and HT, the composition of gut microbiota in HT with different thyroid function status has been less studied.…”

Section: Introductionmentioning

confidence: 99%

The Composition of Gut Microbiota in Patients Bearing Hashimoto’s Thyroiditis with Euthyroidism and Hypothyroidism

Liu

Cao

et al. 2020

International Journal of Endocrinology

View full text Add to dashboard Cite

Aims. Hashimoto’s thyroiditis (HT), a type of autoimmune disease, occurs due to genetic predisposition and environmental factors. It is well known that thyroid function may affect the gut microbiota. However, the composition of gut microbiota in HT patients with different thyroid function status has been less highlighted. Therefore, we focused on the alterations in the composition of gut microbiota in HT patients with euthyroidism and hypothyroidism. Methods. We performed a cross-sectional study, including 45 HT patients with euthyroidism, 18 HT patients with hypothyroidism, and 34 healthy controls. Fecal samples were collected, and microbiota was examined by using 16S RNA ribosomal RNA gene sequencing. Then, we analyzed the possible pathways in relation to the enriched bacteria by linear discriminant analysis (LDA) effect size (LEfSe). Results. Compared with the controls, bacterial richness and diversity were significantly lower in patients with HT, especially in hypothyroidism. Moreover, Lachnospiraceae_incertae_sedis, Lactonifactor, Alistipes, and Subdoligranulum were more enriched in HT patients with euthyroidism, while Phascolarctobacterium was more abundant in those with hypothyroidism. Further analysis suggested that Phascolarctobacterium was negatively related to several pathways, including environmental information processing and metabolism. Conclusion. In summary, our study demonstrated the altered composition of gut microbiota in HT patients with different thyroid function status. Moreover, Phascolarctobacterium may be involved in the development of HT.

show abstract

Chemically or surgically induced thyroid dysfunction altered gut microbiota in rat models

Cited by 16 publications

References 45 publications

Cecal microbial transplantation attenuates hyperthyroid‐induced thermogenesis in Mongolian gerbils

Cecal microbial transplantation attenuates hyperthyroid‐induced thermogenesis in Mongolian gerbils

The Role of the Microbiota in Graves’ Disease and Graves’ Orbitopathy

The Composition of Gut Microbiota in Patients Bearing Hashimoto’s Thyroiditis with Euthyroidism and Hypothyroidism

Contact Info

Product

Resources

About