2023
DOI: 10.1111/php.13781
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Chemiexcitation: Mammalian Photochemistry in the Dark

Abstract: Light is one way to excite an electron in biology. Another is chemiexcitation, birthing a reaction product in an electronically excited state rather than exciting from the ground state. Chemiexcited molecules, as in bioluminescence, can release more energy than ATP. Excited states also allow bond rearrangements forbidden in ground states. Molecules with low-lying unoccupied orbitals, abundant in biology, are particularly susceptible. In mammals, chemiexcitation was discovered to transfer energy from excited me… Show more

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Cited by 9 publications
(9 citation statements)
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References 305 publications
(485 reference statements)
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“…Familiar chemical reactions, even redox reactions, proceed with the electrons in the ground state. Electronically excited states can undergo chemical reactions otherwise forbidden by quantum chemistry, due to altered molecular orbital shapes ( 28 ). Vitamin D synthesis by sunlight's UV radiation is one such reaction.…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…Familiar chemical reactions, even redox reactions, proceed with the electrons in the ground state. Electronically excited states can undergo chemical reactions otherwise forbidden by quantum chemistry, due to altered molecular orbital shapes ( 28 ). Vitamin D synthesis by sunlight's UV radiation is one such reaction.…”
Section: Discussionmentioning
confidence: 99%
“…The potential chemistry is clarified by comparing photoexcitation, in which a photon excites a molecule from its electronic ground state, with chemiexcitation, in which a reaction product is born in the excited state ( 28 ). Photodegradation of A2E has been intensely studied, motivated by its toxicity ( 21 ), yet the chemical mechanism is controversial.…”
Section: Discussionmentioning
confidence: 99%
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“…For example, the thermolysis of dioxetane produces highly reactive triplet excited carbonyl species (18,23), which subsequently decay to the ground state emitting light in the visible region or transfer energy to molecular oxygen, resulting in the production O2 ( 1 ∆g) (23,24) (Fig 1). Notably, the production of chemiexcited species has attracted attention in recent years due to its implications in skin cancer and eye diseases (25)(26)(27). Additionally, lipid hydroperoxides can react with metal ions, heme proteins, or other oxidants, producing alkoxyl and peroxyl radicals (28).…”
Section: Introductionmentioning
confidence: 99%