Chemiluminescence detection coupled to liquid chromatography for the determination of penicillamine in human urine

Zhang, Z.; Baeyens, Willy R. G.; Zhang, X.; Zhao, Yining; Weken, G. Van der

doi:10.1016/s0003-2670(97)00171-2

Cited by 38 publications

(14 citation statements)

References 21 publications

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“…It is of great importance and significance for life science. Up till now, various different methods have already been applied for the determination of penicillamine, such as spectrophotometry [1,2], fluorescence spectrophotometry [3,4], flow injection analysis [5,6], voltammetry [7,8], capillary electrophoresis [9], HPLC method [10], HPLC-UV method [11], LC-UV method [12], chemiluminescence-LC method [13], electrochemical analysis [14], etc. However, most of the methods mentioned above need either complicated and expensive equipment or tedious procedures.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Penicillamine in Pharmaceutical Sample using Fe(III)-Tiron System

Xi¹,

Tu²

2017

Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)

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Abstract-Hydrosulfuryl(-SH) in penicillamine molecule can reduce Fe(III) to Fe(II), then using tiron as chromogenic reagent of Fe(III), and the content of penicillamine is determinated indirectly through determinating the surplus content of Fe(III) in the system. An accurate fast spectrophotometric method for the determination of penicillamine by discoloration spectrophotometry using Fe(III)-tiron system has been established. The various effect factors on the determination of penicillamine using Fe(III)-tiron system have been investigated in detail. The results show that when the reaction temperature was 85℃,the reaction time was 20 min, the dosage of pH3.0 buffer solution was 15.00mL, the dosage of Fe(III) was 2.30mL, the dosage of tiron was 1.00mL, the maximum absorption wavelength of the complex of Fe(III)-tiron was 660 nm, good linear relationship was obtained between △A and the concentration of penicillamine in the range of 0.008000~0.04800 mg· mL -1 ,the equation of the linear regression was △A=0.0074+7.575C(mg· mL -1 ), with a linear correlation coefficient was 0.9993.This proposed method had been successfully applied to determinate of penicillamine in real pharmaceutical.

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Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Penicillamine in Pharmaceutical Sample using Fe(III)-Tiron System

Xi¹,

Tu²

2017

Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)

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“…Several methods have been proposed for the determination of penicillamine (PA) in biological specimens and pharmaceutical formulations. Up to now, PA has been determined by HPLC with fluorescence [5], chemiluminescence [6] and mercury-based electrochemical [7] detection. Various spectrophotometric methods [8][9][10] and electrochemical methods [11][12][13][14][15][16][17] have also been proposed for the determination of PA.…”

Section: Introductionmentioning

confidence: 99%

N‐(3,4‐Dihydroxyphenethyl)‐3,5‐dinitrobenzamide‐Modified Multiwall Carbon Nanotubes Paste Electrode as a Novel Sensor for Simultaneous Determination of Penicillamine, Uric acid, and Tryptophan

2011

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N-(3,4-dihydroxyphenethyl)-3,5-dinitrobenzamide modified multiwall carbon nanotubes paste electrode was used as a voltammetric sensor for oxidation of penicillamine (PA), uric acid (UA) and tryptophan (TP). In a mixture of PA, UA and TP, those voltammograms were well separated from each other with potential differences of 300, 610, and 310 mV, respectively. The peak currents were linearly dependent on PA, UA and TP concentrations in the range of 0.05-300, 5-420, and 1.0-400 mmol L À1, with detection limits of 0.021, 2.0, and 0.82 mmol L À1, respectively. The modified electrode was used for the determination of those compounds in real samples.

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“…This suggests that monitoring the concentrations of this drug in biological fluids over the course of therapy is in high demand. 2 Various methods have been developed for the determination of d-PA in biological specimens and pharmaceutical formulations, including capillary electrophoresis with laser-induced fluorescence, [3][4][5] online vapor-phase generation combined with Fourier transform infrared spectrometry, 6 HPLC (with fluorescence, 7,8 chemiluminescence, 9 and UV detections, 2,10,11 respectively), spectrophotometry, [12][13][14] and electrochemical methods. 15,16 The methods of capillary electrophoresis, [3][4][5] and online vapor-phase generation, 6 are high cost, time-consuming and need special training.…”

Section: Introductionmentioning

confidence: 99%

Utilization of a novel Ag(III)-luminol chemiluminescence system for determination of d-penicillamine in human urine samples

Ma¹,

Fan²,

Xu³

et al. 2011

J. Braz. Chem. Soc.

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. O desvio padrão relativo é 0,23% para 11 repetições de 0,06 μg mL -1 de d-penicilamina. O método tem sido aplicado com sucesso às determinações de d-penicilamina em preparações farmacêuticas e amostras de urina, proporcionando resultados satisfatórios. Com base nos espectros de quimioluminescência e no experimento de aprisionamento de radicais livres realizado neste trabalho, um possível mecanismo de reação para esse sistema reacional é sugerido.A novel sensitive chemiluminescence (CL) system ([Ag(HIO 6 ) 2 ] 5− -luminol reaction system), coupled with a flow injection, is introduced for determination of d-penicillamine. The system is based on the enhancement effect of chemiluminescence reaction by penicillamine in alkaline medium. Under the optimum conditions, the CL intensity is proportional to the concentrations of d-penicillamine with a good linearity. The linear range covers 1.5-150 ng mL -1 and the limit of detection of the method is 0.8 ng mL -1 . The relative standard deviation is 0.23% for 11 repeated measurements of 0.06 μg mL -1 d-penicillamine. The method has been successfully applied to the determinations of d-penicillamine in pharmaceutical preparations and urine samples, giving rise to satisfactory results. Based on the chemiluminescent spectra and free radical trapping experiment performed in this work, a possible reaction mechanism for this reaction system is suggested.

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Chemiluminescence detection coupled to liquid chromatography for the determination of penicillamine in human urine

Cited by 38 publications

References 21 publications

Spectrophotometric Determination of Penicillamine in Pharmaceutical Sample using Fe(III)-Tiron System

Spectrophotometric Determination of Penicillamine in Pharmaceutical Sample using Fe(III)-Tiron System

N‐(3,4‐Dihydroxyphenethyl)‐3,5‐dinitrobenzamide‐Modified Multiwall Carbon Nanotubes Paste Electrode as a Novel Sensor for Simultaneous Determination of Penicillamine, Uric acid, and Tryptophan

Utilization of a novel Ag(III)-luminol chemiluminescence system for determination of d-penicillamine in human urine samples

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