Chemiluminescence in the reaction of 1,2,4,5-tetraoxanes with ferrous ions in the presence of xanthene dyes: fundamentals and perspectives of analytical applications

Kazakov, Dmitry V.; Nazyrov, T. I.; Safarov, F. E.; Yaremenko, Ivan A.; Terent’ev, Alexander O.

doi:10.1039/c8pp00472b

Cited by 2 publications

(2 citation statements)

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“…It was found that 197a‐b had much lower AM activity (IC 50 > 10 −5 mol/L) toward D6 and W2 strains than 196 (WR 14899929) and tetraoxane 197c (Figure 49). 283–286 …”

Section: Some Antimalarial Endoperoxide Moieties Other Than 124‐triox...mentioning

confidence: 99%

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An overview on the antimalarial activity of 1,2,4‐trioxanes, 1,2,4‐trioxolanes and 1,2,4,5‐tetraoxanes

Shukla

Rathi

Hassam³

et al. 2023

Medicinal Research Reviews

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The demand for novel, fast‐acting, and effective antimalarial medications is increasing exponentially. Multidrug resistant forms of malarial parasites, which are rapidly spreading, pose a serious threat to global health. Drug resistance has been addressed using a variety of strategies, such as targeted therapies, the hybrid drug idea, the development of advanced analogues of pre‐existing drugs, and the hybrid model of resistant strains control mechanisms. Additionally, the demand for discovering new potent drugs grows due to the prolonged life cycle of conventional therapy brought on by the emergence of resistant strains and ongoing changes in existing therapies. The 1,2,4‐trioxane ring system in artemisinin (ART) is the most significant endoperoxide structural scaffold and is thought to be the key pharmacophoric moiety required for the pharmacodynamic potential of endoperoxide‐based antimalarials. Several derivatives of artemisinin have also been found as potential treatments for multidrug‐resistant strain in this area. Many 1,2,4‐trioxanes, 1,2,4‐trioxolanes, and 1,2,4,5‐tetraoxanes derivatives have been synthesised as a result, and many of these have shown promise antimalarial activity both in vivo and in vitro against Plasmodium parasites. As a consequence, efforts to develop a functionally straight‐forward, less expensive, and vastly more effective synthetic pathway to trioxanes continue. This study aims to give a thorough examination of the biological properties and mode of action of endoperoxide compounds derived from 1,2,4‐trioxane‐based functional scaffolds. The present system of 1,2,4‐trioxane, 1,2,4‐trioxolane, and 1,2,4,5‐tetraoxane compounds and dimers with potentially antimalarial activity will be highlighted in this systematic review (January 1963–December 2022).

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“…It was found that 197a‐b had much lower AM activity (IC 50 > 10 −5 mol/L) toward D6 and W2 strains than 196 (WR 14899929) and tetraoxane 197c (Figure 49). 283–286 …”

Section: Some Antimalarial Endoperoxide Moieties Other Than 124‐triox...mentioning

confidence: 99%

“…(Figure 49). [283][284][285][286] T A B L E 31 In vitro and in vivo activity of tetraoxanes against P. berghei. 288 It significantly reduced the parasitic liver burden in mice by up to 91% at 100 mg/ kg.…”

Section: 245-tetraoxanes Bearing Amino-alkyl Linkersmentioning

confidence: 99%

An overview on the antimalarial activity of 1,2,4‐trioxanes, 1,2,4‐trioxolanes and 1,2,4,5‐tetraoxanes

Shukla

Rathi

Hassam³

et al. 2023

Medicinal Research Reviews

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Determination of thiourea by terbium (III)/ prulifloxacin sensitized potassium permanganate-sulfite chemiluminescence with quenching method

Chen

2022

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Chemiluminescence in the reaction of 1,2,4,5-tetraoxanes with ferrous ions in the presence of xanthene dyes: fundamentals and perspectives of analytical applications

Abstract: The reaction of biologically active bridged 1,2,4,5-tetraoxanes and diperoxide of trifluoroacetone with Fe2+ ions in the presence of xanthenes, methylene blue and methylene green is accompanied by bright chemiluminescence.

Cited by 2 publications

References 64 publications

An overview on the antimalarial activity of 1,2,4‐trioxanes, 1,2,4‐trioxolanes and 1,2,4,5‐tetraoxanes

An overview on the antimalarial activity of 1,2,4‐trioxanes, 1,2,4‐trioxolanes and 1,2,4,5‐tetraoxanes

Determination of thiourea by terbium (III)/ prulifloxacin sensitized potassium permanganate-sulfite chemiluminescence with quenching method

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