The synthesis and X-ray diffraction established the structure of (7R,8S)-(see text for symbol)-(13R,17R)-trioxolaneabietic acid. Predicted by the computer system PASS antineoplastic activity and the ability to induce apoptosis, a mechanism of cell death, is correlated with experimentally shown cytotoxic activity against malignant cell line MeWo. Results of tests on animals have shown that abietic acid and its 9R,11S-epoxy-12R,15R-trioxolane derivative have anti-inflammatory and antiulcer activity in the absence of adverse effects on animal organisms.

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Decomposition of 1,4-dimethylnaphthalene endoperoxide, which is the source of singlet oxygen, in the presence of β-diketonates of europium(III), neodymium(III) and ytterbium(III) is accompanied by bright chemiluminescence (CL) in visible and near infra-red spectral region due to characteristic emission from the lanthanides at λmax = 615 and 710 nm ((5)D0→(7)F2 and (5)D0→(7)F4 transitions of Eu(3+)), 900 nm ((4)F3/2→(4)I9/2 transition of Nd(3+)) and 1000 nm ((2)F5/2→(2)F7/2 transition of Yb(3+)). Singlet oxygen is the key intermediate responsible for the observed CL, which is presumably generated by the reaction of (1)O2 with ligands of the complexes. The CL phenomenon discovered herein paves the way towards the development of lanthanide-based CL probe for (1)O2.

The reaction of biologically active bridged 1,2,4,5-tetraoxanes and diperoxide of trifluoroacetone with Fe2+ ions in the presence of xanthenes, methylene blue and methylene green is accompanied by bright chemiluminescence.