Chemiluminescence resonance energy transfer imaging on magnetic particles for single-nucleotide polymorphism detection based on ligation chain reaction

Bi, Sai; Zhang, Zhipeng; Dong, Ying; Wang, Zonghua

doi:10.1016/j.bios.2014.10.025

Cited by 39 publications

(13 citation statements)

References 27 publications

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“…Chemiluminiscence resonance energy transfer from peroxidase-mimicking DNAzyme catalyzed luminal-H 2 O 2 to fluorescein with real-time imaging on magnetic particles was reported as a novel LCR methodology in 2015 [95]. Two pairs of complementary probes are used in this assay (Fig.…”

Section: Integrating Lcr Based Dnazyme-fluorescein Chemiluminescence mentioning

confidence: 99%

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Advances in ligase chain reaction and ligation-based amplifications for genotyping assays: Detection and applications

Gibriel

Adel

2017

Mutation Research/Reviews in Mutation Research

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Genetic variants have been reported to cause several genetic diseases. Various genotyping assays have been developed for diagnostic and screening purposes but with certain limitations in sensitivity, specificity, cost effectiveness and/or time savings. Since the discovery of ligase chain reaction (LCR) in the late nineties, it became one of the most favored platforms for detecting these variants and also for genotyping low abundant contaminants. Recent and powerful modifications with the integration of various detection strategies such as electrochemical and magnetic biosensors, nanoparticles (NPs), quantum dots, quartz crystal and leaky surface acoustic surface biosensors, DNAzyme, rolling circle amplification (RCA), strand displacement amplification (SDA), surface enhanced raman scattering (SERS), chemiluminescence and fluorescence resonance energy transfer have been introduced to both LCR and ligation based amplifications to enable high-throughput and inexpensive multiplex genotyping with improved robustness, simplicity, sensitivity and specificity. In this article, classical and up to date modifications in LCR and ligation based amplifications are critically evaluated and compared with emphasis on points of strength and weakness, sensitivity, cost, running time, equipment needed, applications and multiplexing potential. Versatile genotyping applications such as genetic diseases detection, bacterial and viral pathogens detection are also detailed. Ligation based gold NPs biosensor, ligation based RCA and ligation mediated SDA assays enhanced detection limit tremendously with a discrimination power approaching 1.5aM, 2aM and 0.1fM respectively. MLPA (multiplexed ligation dependent probe amplification) and SNPlex assays have been commercialized for multiplex detection of at least 48 SNPs at a time. MOL-PCR (multiplex oligonucleotide ligation) has high-throughput capability with multiplex detection of 50 SNPs/well in a 96 well plate. Ligase detection reaction (LDR) is one of the most widely used LCR versions that have been successfully integrated with several detection strategies with improved sensitivity down to 0.4fM.

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Section: Integrating Lcr Based Dnazyme-fluorescein Chemiluminescence mentioning

confidence: 99%

“…Chemiluminescence and CRET have been widely used in the detection of LCR products as reported previously [95,97]. In chemiluminescence, light is emitted in response to a chemical reaction while in CRET, the produced chemiluminescence excites the acceptor dye once gets in close proximity.…”

Section: Chemiluminescence and Chemiluminescence Resonance Energy Tramentioning

confidence: 99%

Advances in ligase chain reaction and ligation-based amplifications for genotyping assays: Detection and applications

Gibriel

Adel

2017

Mutation Research/Reviews in Mutation Research

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“…Magnetic particles exhibit physicochemical stability enabling them to detect the targets with no deleterious biological effects and importantly do not chemically interact with the target that is sought. Consequently, they have been extensively utilized in medical applications such as immunoassays [ 18 ], magnetic resonance imaging (MRI) [ 19 ], nucleic acid detection [ 20 ] and magnetic separation [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Magneto-Impedance Biosensor Sensitivity: Effect and Enhancement

Sayad

Skafidas

Kwan

2020

Sensors

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Biosensors based on magneto-impedance (MI) effect are powerful tools for biomedical applications as they are highly sensitive, stable, exhibit fast response, small in size, and have low hysteresis and power consumption. However, the performance of these biosensors is influenced by a variety of factors, including the design, geometry, materials and fabrication procedures. Other less appreciated factors influencing the MI effect include measuring circuit implementation, the material used for construction, geometry of the thin film sensing element, and patterning shapes compatible with the interface microelectronic circuitry. The type magnetic (ferrofluid, Dynabeads, and nanoparticles) and size of the particles, the magnetic particle concentration, magnetic field strength and stray magnetic fields can also affect the sensor sensitivity. Based on these considerations it is proposed that ideal MI biosensor sensitivity could be achieved when the sensor is constructed in sandwich thick magnetic layers with large sensing area in a meander shape, measured with circuitry that provides the lowest possible external inductance at high frequencies, enclosed by a protective layer between magnetic particles and sensing element, and perpendicularly magnetized when detecting high-concentration of magnetic particles.

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“…Biosensing principles which employ magnetic particles for concentration, separation or washing steps only are excluded from this review as well as chip-based measurement approaches involving microfluidics. Here, we refer to the existing review literature [ 68 , 69 , 70 , 71 , 72 , 73 ].…”

Section: Introductionmentioning

confidence: 99%

Homogeneous Biosensing Based on Magnetic Particle Labels

Schrittwieser

Pelaz

Parak

et al. 2016

Sensors

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The growing availability of biomarker panels for molecular diagnostics is leading to an increasing need for fast and sensitive biosensing technologies that are applicable to point-of-care testing. In that regard, homogeneous measurement principles are especially relevant as they usually do not require extensive sample preparation procedures, thus reducing the total analysis time and maximizing ease-of-use. In this review, we focus on homogeneous biosensors for the in vitro detection of biomarkers. Within this broad range of biosensors, we concentrate on methods that apply magnetic particle labels. The advantage of such methods lies in the added possibility to manipulate the particle labels by applied magnetic fields, which can be exploited, for example, to decrease incubation times or to enhance the signal-to-noise-ratio of the measurement signal by applying frequency-selective detection. In our review, we discriminate the corresponding methods based on the nature of the acquired measurement signal, which can either be based on magnetic or optical detection. The underlying measurement principles of the different techniques are discussed, and biosensing examples for all techniques are reported, thereby demonstrating the broad applicability of homogeneous in vitro biosensing based on magnetic particle label actuation.

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Chemiluminescence resonance energy transfer imaging on magnetic particles for single-nucleotide polymorphism detection based on ligation chain reaction

Cited by 39 publications

References 27 publications

Advances in ligase chain reaction and ligation-based amplifications for genotyping assays: Detection and applications

Advances in ligase chain reaction and ligation-based amplifications for genotyping assays: Detection and applications

Magneto-Impedance Biosensor Sensitivity: Effect and Enhancement

Homogeneous Biosensing Based on Magnetic Particle Labels

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