ChemInform Abstract: A New Route Toward 4‐Substituted Pyrazino[2,1‐b]quinazoline‐3,6‐dione Systems. Total Synthesis of Glyantrypine.

Abstract

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Discovery of glyantrypine‐family alkaloids as novel antiviral and antiphytopathogenic‐fungus agents

“…6 Since Mantle's research group 7 isolated the glyantrypine-family alkaloids from the secondary metabolites of Aspergillus clavatus, it has been found that glyantrypine-family alkaloids had moderate cytotoxicity to leukemia cell line P388 8 and played an important role in the treatment of cardiovascular diseases, 9 influenza virus, 10 neuroprotection, 11 anticarcinoma, 12 and other aspects. The broad-spectrum biological activities and unique structural skeleton of these alkaloids have attracted the attention of synthetic chemists, and a series of synthetic methods of these alkaloids have been reported, which can be divided into two categories: the Eguchi aza Wittig synthetic method [13][14][15] and the Mazurkiewicz-Ganesan synthetic method. [16][17][18] In the Eguchi aza Wittig synthesis method, the pyrazine [2,1-b] quinazoline-3,-6-dione skeleton was synthesized by selective acylation of diketpiperazine with o-azido benzoyl chloride and cyclization.…”