ChemInform Abstract: A Novel “Domino‐Click Approach” to Unsymmetrical Bis‐1H‐1,2,3‐triazoles.

Abstract

Triazole derivatives R 0280A Novel "Domino-Click Approach" to Unsymmetrical Bis-1H-1,2,3-triazoles. -Aryl azides react with 2 molecules of allenylmagnesium bromide in a domino addition reaction to give 5-butynylated triazoles (III) instead of the 4-butynylated isomers. A "click reaction" with aryl azides affords the bis-triazoles in quantitative yields. -(BANDAY, A. H.; ARORA, B. S.; ALAM, M. S.; KUMAR*, H. M. S.; Helv. Chim.