ChemInform Abstract: Antiviral Activity of 1‐Amino‐1,2,3,4‐tetrahydrocarbazoles.

Abstract

In continuation of studies of the antimicrobical activity in the 1‐amino‐1,2,3,4‐tetrahydrocarbazole series, the compounds (IV) are prepared by reductive amination of the carbazolones (I).

Palladium-Catalyzed Amination and Amidation of Benzo-Fused Bromine-Containing Heterocycles

“…1-Alkylaminotetrahydrocarbazoles exhibit antiviral [3], antifungal, and antibacterial activity [4,5] and are also active against Mycobacterium tuberculosis [5]. The parent compound of this series, 1-aminotetrahydrocarbazole was also found to be active against Mycobacterium tuberculosis [6,7], while 3-dimethylamino-1,2,3,4-tetrahydrocarbazole showed antidepressant activity [7].…”