ChemInform Abstract: Basic Ionic Liquid Promoted Heterocyclization to Access Fused Imidazopyridines.

Siddiqui, I. R.; Shireen, Shireen; Shamim, Shayna; Waseem, Malik A.; Abumhdi, Afaf A. H.; Srivastava, Arjita; Srivastava, Anjali

doi:10.1002/chin.201401186

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“…Table 3 shows important examples of advanced synthesis of drugs molecules using IL media. There are also many reports on the synthesis of molecules, which can be used as precursors for potential drugs with various activities and contain sulfonamide, 672 lactam, 675 imidazole, 707,708 pyrazolone, 709 thiazole, 710,711 or thiazolidine 712,713 cores.…”

Section: Ionic Liquids In Drug Synthesismentioning

confidence: 99%

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

2017

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Ionic liquids are remarkable chemical compounds, which find applications in many areas of modern science. Because of their highly tunable nature and exceptional properties, ionic liquids have become essential players in the fields of synthesis and catalysis, extraction, electrochemistry, analytics, biotechnology, etc. Apart from physical and chemical features of ionic liquids, their high biological activity has been attracting significant attention from biochemists, ecologists, and medical scientists. This Review is dedicated to biological activities of ionic liquids, with a special emphasis on their potential employment in pharmaceutics and medicine. The accumulated data on the biological activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible applications in drug synthesis and drug delivery systems. Dedicated attention is given to a novel active pharmaceutical ingredient-ionic liquid (API-IL) concept, which suggests using traditional drugs in the form of ionic liquid species. The main aim of this Review is to attract a broad audience of chemical, biological, and medical scientists to study advantages of ionic liquid pharmaceutics. Overall, the discussed data highlight the importance of the research direction defined as "Ioliomics", studies of ions in liquids in modern chemistry, biology, and medicine.

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