ChemInform Abstract: Benzodipyrans of Expected Biological Activity.

Hishmat, O. H.; Khalil, Khadijeh; Galil, F. M. Abdel; El-Naem, Sh. I.; Magd-El-Din, Asmaa A.

doi:10.1002/chin.199023193

Cited by 4 publications

(4 citation statements)

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“…The reaction mechanism involves an initial formation of the corresponding ylidene compounds followed by aminolysis of pyrone ring thereafter, nucleophilic attacking of the amino group to the cyano or the ester group simultaneously to form the products 10a,b. Change of the reaction conditions in some analogue compounds gave different products as outlined in the literature [33] The assigned structure of 10a and 10b were confirmed by spectral and the elemental analysis. The infra-red spectra revealed in addition to the hydroxyl and amino absorption bands, the characteristic (C N) band at = 2227 cm -1 as well as an amidic absorption band (compound 10b) at = 1640 and 1576 cm -1 indicative of the amide form concerning compound 10b.…”

Section: Resultssupporting

confidence: 52%

Synthesis and reactions of some new benzopyranone derivatives with potential biological activities

El‐Desoky

Al‐Shihry

2008

Journal of Heterocyclic Chem

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O O OCH 3 O CH=X X=O, NH, CN, cyclohex., Indandione O OH OCH 3 O N CN NH 2 10a O O OCH 3 O X N 16a-e R O O OCH 3 CH 3 O X Ar 18 -21 3 -9 X= O, SReaction of visnaginone which derived from the naturally occurring compound "visnagine", with allyl bromide gave O-allyl visnaginone 1, which underwent Claisen rearrangement to yield 7-allylbenzofuran 2 derivative. Vilsmeier Haack formylation of 2 afforded our versatile starting compound furochromene-6carboxaldehyde (3) which was condensed with cyclohexane-1,3-dione, indandione, malononitrile or ethyl cyanoacetate to yield the ylidene nicotinonitrile and pyridone derivatives 4,7,10a-b. Reaction of 3 with aniline or aniline acting on multiple function X-H (X = NH, O, S) at its ortho position afforded the corresponding anils, imidazolylfurochromene and azepines compounds 11-17. On the other hand, oxidation of visnagin afforded chromene-6-carboxaldehyde derivative 18 which was condensed with different aryl or (heteroaryl) acetonitrile followed by hydrolysis to give pyrano[3,2-g]chromen-4,8-dione derivatives 20a-d and 22.

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Section: Resultssupporting

confidence: 52%

Synthesis and reactions of some new benzopyranone derivatives with potential biological activities

El‐Desoky

Al‐Shihry

2008

Journal of Heterocyclic Chem

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“…9-dimethoxy-5-oxo-5H-furo[3,2-g]chromene-6-carbaldehyde was prepared by a published Vilsmier-Haack reaction. [27][28][29][30]…”

Section: Chemistry Materialsmentioning

confidence: 99%

“…2H,30,34 C-H), 7.30 (t, 1H,35 C-H), 4.10 (s, 3H, O28 CH 3 ), 2.42 (s, 3H, N-10 CH 3 ), 3.14 (s, 3H, C-7 CH 3 ). UV.…”

mentioning

confidence: 99%

In vitro antimicrobial activity evaluation of newly synthesized furochromone Schiff base complexes

et al. 2018

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“…[33][34][35] Standard analytical methods were used to determine the metal ion content. [36][37][38][39] IR spectra of the ligand and its metal complexes were measured using KBr discs with a Jasco FT/IR 300E Fourier transform infrared spectrophotometer covering the range 400-4000 cm…”

Section: Physical Measurementsmentioning

confidence: 99%

Anti‐proliferative activity of newly synthesized Cd(II), Cu(II), Zn(II),Ni(II), Co(II), VO(II), and Mn(II) complexes of 2‐((4,9‐dimethoxy‐5‐oxo‐5H‐furo[3,2‐g]chromen‐6‐yl)methylene) hydrazinecarbothioamide on three human cancer cells

Shakdofa

Mousa

Elseidy

et al. 2017

Applied Organom Chemis

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Thiosemicarbazone ligand, 2-((4,9-dimethoxy-5-oxo-5H-furo[3,2-g]chromen-6-yl) methylene) hydrazinecarbothioamide and its Cd(II), Cu(II), Zn(II), Ni(II), Co(II), VO(II), and Mn(II) complexes have been prepared and characterized by various spectroscopic and analytical techniques. Complexes molar conductance measurements displayed that all complexes (2-8) are non-electrolyte. With general compo-Based on analytical and spectral measurements, the octahedral or distorted octahedral geometries suggested for complexes. Ligand and complexes anti-proliferative activities were assessed against three various human tumor cell lines including breast cancer (MCF-7), liver cancer (HepG2) and lung cancer (A549) using SRB fluorometric assay and cis-platin as positive control. The anti-proliferative activity result indicated that the ligand and its complexes have considerable anti-proliferative activity analogous to that of ordinarily utilized anti-cancer drug (cis-platin). They do their anti-cancer activities by modifying free radical's generation via raising the superoxide dismutase activity and depletion of intracellular reduced glutathione level, catalase, glutathione peroxidase activities, escorted by highly generation of hydrogen peroxide, nitric oxide and other free radicals leading to tumor cells death, as monitoring by decreasing the protein and nucleic acids synthesis.

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ChemInform Abstract: Benzodipyrans of Expected Biological Activity.

Cited by 4 publications

References 0 publications

Synthesis and reactions of some new benzopyranone derivatives with potential biological activities

Synthesis and reactions of some new benzopyranone derivatives with potential biological activities

In vitro antimicrobial activity evaluation of newly synthesized furochromone Schiff base complexes

Anti‐proliferative activity of newly synthesized Cd(II), Cu(II), Zn(II),Ni(II), Co(II), VO(II), and Mn(II) complexes of 2‐((4,9‐dimethoxy‐5‐oxo‐5H‐furo[3,2‐g]chromen‐6‐yl)methylene) hydrazinecarbothioamide on three human cancer cells

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