ChemInform Abstract: Capillary Zone Electrophoresis in Pharmaceutical Analysis

Fanali, Salvatore; Cristalli, M.; Nardi, Annalisa; Ossicini, L.; Sk, Shukla

doi:10.1002/chin.199052399

Cited by 3 publications

(2 citation statements)

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“…Further increases in voltage resulted in decreased efficiencies. The explanation for this is that the capillary becomes less effective in heat dissipation after a certain voltage level, where excessive Joule heat is generated 46. As heat is produced inside the capillary, the viscosity of the buffer decreases, and sample diffusion resulting in peak broadening becomes significant.…”

Section: Resultsmentioning

confidence: 99%

Development of a stability‐indicating CE assay for the determination of amlodipine enantiomers in commercial tablets

et al. 2008

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A simple, accurate, precise and sensitive method using CD for separation and stability indicating assay of enantiomers of amlodipine in the commercial tablets has been established. Several types of CD were evaluated and best results were obtained using a fused-silica capillary with phosphate running buffer (100 mM, pH 3.0) containing 5 mM hydroxypropyl-alpha-CD. The method has shown adequate separation for amlodipine enantiomers from its degradation products. The drug was subjected to oxidation, hydrolysis, photolysis and heat to apply stress conditions. The range of quantitation for both enantiomers was 5-150 microg/mL. Intra- and inter-day RSD (n=6) was <4%. The limit of quantification that produced the requisite precision and accuracy was found to be 5 microg/mL for both enantiomers. The LOD for both enantiomers was found to be 0.5 microg/mL. Degradation products produced as a result of stress studies did not interfere with the detection of enantiomers and the assay can thus be considered stability indicating.

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