ChemInform Abstract: Cascade Synthesis of Substituted 4‐Amino‐1,2,4‐triazol‐3‐ones from Aldehyde Hydrazones and Azodicarboxylates.

Abstract

Cascade Synthesis of Substituted 4-Amino-1,2,4-triazol-3-ones from Aldehyde Hydrazones and Azodicarboxylates. -Reaction of aromatic aldehyde hydrazones with azodicarboxylates in the presence of PPh3 allows an efficient and general access to 4-aminotriazolones of type (III). Starting from aliphatic aldehyde hydrazones, adducts like (V) are obtained, which provide the desired triazolones after treatment with TFA. -(SU, Y.; JIANG, Z.; HONG, D.; LU*, P.; WANG, Y.; LIN, X.; Tetrahedron