No abstract

No abstract

Substituted triazolinones were prepared by a three-component reaction of aldehydes, hydrazines and azodicarboxylates using TFA as a catalyst. The procedure was convenient and efficient, utilizing readily available substrates. A plausible mechanism for the cascade process is proposed. triazolinones, cascade reactions, multicomponent reactions (MCRs), azodicarboxylates Citation:Su Y H, Jiang Z, Hong D, et al. One pot cascade synthesis of substituted 1,2,4-triazol-3-ones.

Cascade Synthesis of Substituted 4-Amino-1,2,4-triazol-3-ones from Aldehyde Hydrazones and Azodicarboxylates. -Reaction of aromatic aldehyde hydrazones with azodicarboxylates in the presence of PPh3 allows an efficient and general access to 4-aminotriazolones of type (III). Starting from aliphatic aldehyde hydrazones, adducts like (V) are obtained, which provide the desired triazolones after treatment with TFA. -(SU, Y.; JIANG, Z.; HONG, D.; LU*, P.; WANG, Y.; LIN, X.; Tetrahedron