Synthesis and antitumor activity of new shikonin glycosides

Shikonin Derivatives Protect Immune Organs from Damage and Promote Immune Responses In Vivo in Tumour‐bearing Mice

“…Several authors have investigated ShD‐mediated tumour suppression and its in vitro underlying mechanisms (Chang et al , ; Lee et al , ; Su et al , ; Yang et al , ; Yao and Zhou, ), including induction of apoptosis via the activation of signalling pathways involved in reactive oxygen species formation (Chang et al , ), p53, p27, Bcl‐2 or caspases (Hsu et al , ) and inhibition of tumour propagation via telomerase and DNA topoisomerase I/II blockade (Fujii et al , ). However, little is known about the in vivo effects of ShD on the immune function and immune organ morphology of mice bearing transplantable neoplasms.…”

Synthesis of several novel 14-membered ketolides bearing modified 5-O-4′-[1,2,3] triazol desosamine side chain

“…The 1-methyoxyl of 4a was acetylated in a mixture of acetic anhydride, acetic acid, and sulfuric acid (1:0.4:0.1), 14 and then converted to 1-hydroxyl by hydrazine acetate to give compound 6. 15 The glycosylation was hard to proceed due to the steric hindrance and low reactivity of the 5-hydroxyl group in compound 9. Two kinds of donor were used to study glycosylation reaction: the fluoro donor 7 and the trichloroacetimidate donor 8.…”

The synthesis of thioglucosides substituted 1,4-naphthoquinones and their conversion in oxathiane fused quinone-thioglucoside conjugates

“…Also, conjugation of naphthoquinones with carbohydrates led to the novel structures with new types of biological activity. [8][9][10][11] In the course of our drug research project we developed an effective method for preparation of naphthoquinone acetylthioglucosides by the condensation of available substituted chloroquinones 1a,b with tetra-O-acetyl-1-thio-β-D-glucopyranose (2) (AGSH) and obtained related naphthoquinone acetylglucosides 3a,b. The acetylglucoside naphthoquinones 3a,b readily were deacetylated with MeONa/MeOH and led the water soluble thioglucosides 4a,b.…”