ChemInform Abstract: Chemical Constituents and Pharmacological Properties of Radix Inulae

Huo, Yue; Hm, Shi; My, Wang; Xb, Li

doi:10.1002/chin.200852234

Cited by 10 publications

(10 citation statements)

References 28 publications

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“…The MS spectrum showed a product ion at m/z 203, which was generated from m/z 231 by loss of CO. Based on these results and the findings from our previous research [21], M8 was speculated to be 5, 6-dehydroisoalantolactone.…”

Section: Metabolite M4 Was Observed As Protonated Molecular Ion [M + H]supporting

confidence: 65%

“…All experiments on rats were implemented in accordance with the guidelines set by Shanghai Jiao Tong University Animal Ethics Committee (Shanghai, China). The animals were randomly divided into alantolactone group, isoalantolactone group, and blank group (each with four rats), housed under controlled conditions (temperature: [20][21][22][23][24][25] ∘ C, humidity: 40-70%) with a natural light-dark cycle for 1 week before the experiment. All rats were fasted overnight with water allowed ad libitum, and then a single dose of alantolactone or isoalantolactone was given orally to rats at 90 mg/kg (blank group received oral administration of water).…”

Section: Animal Experimentmentioning

confidence: 99%

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Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration

Wang

Peng

et al. 2018

Journal of Chemistry

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Alantolactone and isoalantolactone are the major active ingredients of Inulae Radix. Their metabolism in vivo and in vitro was investigated by UPLC-Q-TOF-MS for the first time. As a result, nine metabolites in vivo including cysteine conjugates, oxidates, dehydrogenates, and hydrates were detected in rat bile after oral administration. The metabolites produced in vitro by incubation with rat liver microsomes were found to be substantially identical to those detected in vivo. However, no metabolites were detected in the samples of plasma, feces, and urine or in the incubates of gastric juice, intestinal juice, and intestinal bacteria. These results reveal that the liver is the main metabolic organ for alantolactone and isoalantolactone, and the first pass effect of the liver appears to be the reason for the low oral bioavailability of the two lactones.

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Section: Metabolite M4 Was Observed As Protonated Molecular Ion [M + H]supporting

confidence: 65%

Section: Animal Experimentmentioning

confidence: 99%

Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration

Wang

Peng

et al. 2018

Journal of Chemistry

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“…Two representatives from Compositae (Asteracea) (coltfoots and great burdock) and two from Labiate (peppermint and thyme) herbs showed significantly high antioxidant potentials. The high antioxidant activity of coltsfoot could be explained with presence of terpens: arnidol, faradiol, sterols, flavonoids (kaempferol, quercetin and its glycosides, rutin, hiperoside), phenolic acids (ferulic, caffeic, chlorogenic, galic and p-hydroxybenzoic acids) (Ivancheva and Stancheva, 2000;Nedelcheva et al, 2015).…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Elecampane roots are used in folk medicine as infusions and tinctures for curing asthma, bronchitis, lung disorders, tuberculosis, indigestion, chronic enterogastritis, for wound healing, treatment of emesis and diarrhea. Its pharmacological properties include also anti-inflammatory, antioxidant, anticoagulant, anti-tumor, antimicrobial and insecticidal activities (Konishi et al, 2002, Stojakowska et al, 2006, Huo et al, 2008. Echinacea purpurea possesses important immuno-stimulatory and anti-inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

Antioxidants and carbohydrate content in infusions and microwave extracts from eight medicinal plants

2017

J App Pharm Sci

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The aims of the current research were to evaluate and to compare the antioxidant activity and the content of total phenolic, flavonoids and fructan content in infusions and microwave-assisted extracts from eight herbs:and echinacea (Echinacea purpurea Moench.). The total phenolic contents, total flavonoids and antioxidant activity were evaluated by Folin-Ciocalteau, Al(NO3)3 methods and DPPH assays. The total fructans and sugars were determined by resorcinol and HPLC-RID methods. Infusion and microwave-assisted extraction (MAE) were evaluated as efficient methods for preparation of herbal drinks. The highest values of biologically active substances and antioxidant activity were found in MAE herbal extracts. Coltsfoot, thyme and great burdock extracts demonstrated the highest content of total phenolic and flavonoids. Coltsfoot and thyme extracts showed the highest antioxidant activity (334 mM TEg -1 and 287 mM TEg -1 dw, respectively). Fructans were found in coltsfoot (4.6%) and echinacea (3.9 %) leaves, in great burdock, dandelion and elecampane roots -14 %, 34% and 44% dw, respectively. Elecampane and dandelion roots were evaluated as sources of prebiotic inulin.

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“…This pair of structural isomers has been shown to display various pharmacologic activities such as hepatoprotective, antiimflammatory, antitumour, antibacterial, antidematophytic, antifungal activities, etc. [1–5]…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-assisted extraction of alantolactone and isoalantolactone from Inula helenium roots

2010

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This work deals with ultrasound-assisted extraction (UAE) of alantolactone and isoalantolactone from the roots of Inula helenium L., a well-known medicinal plant. The effects of ethanol concentration, extraction time, temperature and number of extraction steps on the extraction yields of both sesquiterpene lactones were investigated. Gas chromatographic (GC) method was used for simultaneous determination of their contents in the corresponding extracts. A comparison with classical extraction methods [maceration, infusion and micro steam distillation-extraction (MSDE)] showed that the amounts of alantolactone and isoalantolactone achieved by UAE with 70 and 96% EtOH for 30 min at room temperature were higher or almost equal to those obtained by maceration for 24 hours.

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ChemInform Abstract: Chemical Constituents and Pharmacological Properties of Radix Inulae

Abstract: Organic chemistry Z 0200 Chemical Constituents and Pharmacological Properties of Radix Inulae -[e.g. terpenes; 39 refs.] -(HUO, Y.; SHI, H. M.; WANG, M. Y.; LI*, X. B.;

Cited by 10 publications

References 28 publications

Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration

Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration

Antioxidants and carbohydrate content in infusions and microwave extracts from eight medicinal plants

Ultrasound-assisted extraction of alantolactone and isoalantolactone from Inula helenium roots

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