ChemInform Abstract: CONDENSED AS‐TRIAZINES. VIII. DIRECT SYNTHESIS OF 1‐SUBSTITUTED TRIAZOLES FUSED TO BENZO‐AS‐TRIAZINE AND PYRIDO(2,3‐E)‐AS‐TRIAZINE RINGS

Abstract

Ringschlußreaktionen zur direkten Synthese der beiden Titelringsysteme werden untersucht, wobei beide Systeme vergleichend betrachtet werden.

Chemosensitisation of drug-resistant and drug-sensitive yeast cells to antifungals

“…The structure-activity correlation study using structural derivatives of CTBT revealed that chlorine on the benzene ring as well as the tetrazolo ring are essential both for antifungal and chemosensitising activities of CTBT. When chlorine was substituted with a hydrogen or methyl group, the chemosensitising activity of corresponding compounds, tetrazolo [5,1-c]benzo [1,2,4]triazine [42] and 7-methyltetrazolo[5,1-c]benzo [1,2,4]triazine [43], was lost and their antifungal activity was diminished. Substitution of nitrogen in the tetrazolo ring with a carbon atom bound to hydrogen (7-chloro [1,2,4]triazolo [3,4-c]benzo [1,2,4]triazine [42]) or to different chemical groups such as C-Br (1-bromo [1,2,4]triazolo [3,4-c]benzo [1,2,4]triazine [41]) or C-CH 3 , C-NH-NH 2 (data not shown) led to loss both of the antimicrobial and chemosensitising activities of corresponding compounds under used experimental conditions (Fig.…”