ChemInform Abstract: DERIVATIVES OF BARBITURIC ACID, XXXIV. SYNTHESIS OF CHIRAL BARBITURATE MANNICH BASES

Knabe, J.; Schmitt, Wolfgang

doi:10.1002/chin.198506248

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“…Mannich bases are a class of organic compounds that have gained interest in pharmaceutical chemistry because of their widespread use. Antibacterial, anti-cancer (Holla et al, 1998(Holla et al, , 2003, analgesic, anti-in lammatory (Goekce et al, 2005), anticonvulsant (Dimmock et al, 1992), antimalarial (Lopes et al, 2004), antiviral (Sriram et al, 2005) and CNS depressant (Knabe et al, 1983) activities were associated with these methods. Detailed studies were carried out on the coordination chemistry of the Mannich bases (Al-Jeboori et al, 2008;Haiduc and Silvestru, 1990), because of the selective nature of the ligands with various metal salts.…”

Section: Introductionmentioning

confidence: 99%

Studies on the Spectral, Anti-Bacterial and Anti-Fungal Activities of 1-((Dicyclohexylamino) (Phenyl) Methyl) Pyrrolidine-2, 5-Dione and Few of its Metal Complexes

Rȧjeswari¹,

Suhana²,

Rajappan³

2020

ijrps

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1-((dicyclohexylamino)(phenyl)methyl) pyrrolidine-2,5-dione (SDB) has been synthesized as a result of succinimide, benzaldehyde and dicyclohexylamine Mannich base condensation and its CoII, NiII and CuII complexes were prepared. The structure of the Mannich Base ligand (SDB) was elucidated on the basis of FT-IR, 1H NMR, 13C NMR and Mass spectral studies. The monomeric and non-electrolytic nature of the metal complexes is evidenced by their magnetic susceptibility and low conductance data studies. Spectral tests, mainly FT-IR studies as well as elemental analysis, were carried out to verify the structures of the newly synthesized compounds. All the metal complexes possess a six-coordinate geometry. The synthesized ligand and its metal complexes have been tested against Gram-positive strains (Staphylococcus aureus and Micrococcus luteus), Gram-negative strains (Escherichia coli and Pseudomonas aeruginosa) and fungal strains (Aspergillus niger and Aspergillus fumigates) for their in vitro anti-bacterial and anti-fungal activities. Preliminary antimicrobial studies of the ligand and their metal complexes have also been carried out in order to understand the toxic effect of ligands and metal complexes against the selective microbes. The results showed that the metal chelates of the ligands showed higher antimicrobial activities than the free ligand SDB and CoII complexes possess higher activity than the other metal complexes.

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Section: Introductionmentioning

confidence: 99%

Studies on the Spectral, Anti-Bacterial and Anti-Fungal Activities of 1-((Dicyclohexylamino) (Phenyl) Methyl) Pyrrolidine-2, 5-Dione and Few of its Metal Complexes

Rȧjeswari¹,

Suhana²,

Rajappan³

2020

ijrps

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ChemInform Abstract: DERIVATIVES OF BARBITURIC ACID, XXXIV. SYNTHESIS OF CHIRAL BARBITURATE MANNICH BASES

Abstract: Barbitursäuren (I) reagieren mit Methyleniminiumchloriden (II) zu racemischen Mannich‐ Basen (III), die nicht in Enantiomere gespalten werden können.

Cited by 1 publication

References 1 publication

Studies on the Spectral, Anti-Bacterial and Anti-Fungal Activities of 1-((Dicyclohexylamino) (Phenyl) Methyl) Pyrrolidine-2, 5-Dione and Few of its Metal Complexes

Studies on the Spectral, Anti-Bacterial and Anti-Fungal Activities of 1-((Dicyclohexylamino) (Phenyl) Methyl) Pyrrolidine-2, 5-Dione and Few of its Metal Complexes

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