ChemInform Abstract: DIFLUORONITROETHYL ETHERS OF ALKYLENE‐1,2‐GLYCOLS AND THEIR DERIVATIVES

Abstract

In verd. Natronlauge reagiert 2,2‐Difluor‐2‐nitroäthanol (I) mit Äthylenoxid (II) unter Bildung der Äther (III) und (IV).

Aliphatic nitro alcohols. Synthesis, chemical transformations and applications

“…The nitro alcohol 244 reacts with ethylene oxide or propylene oxide in the presence of aqueous sodium hydroxide at 0 8C for 16 h to give ethers RCH(OH)CH 2 OCH 2 C(NO 2 )F 2 (R = H, Me) (yields 32% and 67%); in the case of ethylene oxide, the compound F 2 C(NO 2 )CH 2 O(CH 2 ) 2 OCH 2 CH 2 OH is also formed (yield 4%). 173 The reaction of the nitro alcohol 202 with epoxides 259 at 50 8C in the presence of boron trifluoride etherate or sulfuric acid results in the formation of ethers 260 (yields 51% and 46.4%). 174 The compounds CH:C(R)C(OH) CH(R H ) ± OCH 2 CH 2 NO 2 have been obtained by the reaction of the nitro alcohol 202 with epoxides HC:C(R)7…”