ChemInform Abstract: Efficient Synthesis of 2,4‐Dioxohexahydro‐1,3,5‐triazine O‐Acetylglycosyl Glucosides and Their Antiviral Activity.

Chen, H.; Huang, Suzhen; Xie, Jianying

doi:10.1002/chin.201019192

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2012

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“…Based on a literature survey we found that 1,3,5-triazines showed biological activities such as antimicrobial (Chande et al, 1998), antitumour (Brzozowski et al, 2000), anticancer (Saczewski et al, 2006), antimalarial (Gravestock et al, 2011), and antiviral (Chen et al, 2009). So we started our work by choosing 2,4,6-trichloro- [1,3,5]-triazine as starting material.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of s-Triazine-Based Thiazolidinones as Antimicrobial Agents

Patel

Kumari

et al. 2012

Zeitschrift Für Naturforschung C

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A novel series of thiazolidinone derivatives, namely 4-{4-dimethylamino-6-[4-oxo-2-phenyl-5-(4-pyridin-2-yl-piperazin-1-ylmethyl)-thiazolidin-3-yl]-[1,3,5]-triazin-2-yloxy}-1-methyl-1H-quinolin-2-ones, have been synthesized from the key intermediate 4-(4-amino-6-dimethylamino-[1,3,5]-triazin-2-yloxy)-1-methyl-1H-quinolin-2-one (5). Compound 5 was condensed with various aldehydes to give Schiff base derivatives, which after cyclization gave thiazolidinones that were linked with 1-pyridin-2-yl-piperazine to obtain the target compounds. The newly synthesized compounds were evaluated for their antimicrobial activity against eight bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, Shigella fl exneri) and four fungi (Aspergillus niger, Candida albicans, Aspergillus fumigatus, Aspergillus clavatus).

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